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Titolo:
Acute self-limiting hepatitis B after immunoprophylaxis failure in an infant
Autore:
Komatsu, H; Fujisawa, T; Sogo, T; Isozaki, A; Inui, A; Sekine, I; Kobata, M; Ogawa, Y;
Indirizzi:
Natl Def Med Coll, Dept Pediat, Tokorozawa, Saitama 3598513, Japan Natl Def Med Coll Tokorozawa Saitama Japan 3598513 Saitama 3598513, Japan Saitama Med Sch, Dept Pediat, Saitama, Japan Saitama Med Sch Saitama Japan tama Med Sch, Dept Pediat, Saitama, Japan
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 1, volume: 66, anno: 2002,
pagine: 28 - 33
SICI:
0146-6615(200201)66:1<28:ASHBAI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACE-ANTIGEN VARIANTS; INDUCED ESCAPE MUTANT; IMMUNE GLOBULIN; VIRUS MUTANTS; MOLECULAR EPIDEMIOLOGY; LIVER-TRANSPLANTATION; FULMINANT-HEPATITIS; ANTIBODY-RESPONSES; VIRAL PERSISTENCE; CARRIER CHILDREN;
Keywords:
seroconversion; sequencing; deletion mutant; polymerase gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Komatsu, H Natl Def Med Coll, Dept Pediat, 3-2,Namiki, Tokorozawa, Saitama3598513, Japan Natl Def Med Coll 3-2,Namiki Tokorozawa Saitama Japan 3598513 n
Citazione:
H. Komatsu et al., "Acute self-limiting hepatitis B after immunoprophylaxis failure in an infant", J MED VIROL, 66(1), 2002, pp. 28-33

Abstract

The occurrence of acute hepatitis after failure of immunoprophylaxis in cases of mother-to-infant transmission of hepatitis B virus (HBV) is uncommon. Because immunoprophylaxis failure is caused by the emergence of an "a" determinant escape mutant, the infants usually become HBV carriers. To evaluate whether mutations in the S gene coding for the surface protein that contains the "a" determinant are associated with acute hepatitis after immunoprophylaxis failure, HBV DNA of an infant in with acute hepatitis developed with seroconversion to anti-HBs antibodies at 12 months of age despite administration of anti-hepatitis B immunoglobulin and hepatitis B vaccine was analyzed. The S gene from HBV DNA isolated from the serum of the infant at 12, 19, and 27 months of age was cloned and sequenced. Mutations affecting amino acid residues in the first loop within the "a" determinant (codons 124-147) were found at 12 months of age. Moreover, a novel deletion mutant, with a 1-bp deletion at nucleotide 449 of the S gene, was found at 19 and 27 months of age. This deletion resulted in a frame shift and it introduced a stop codon (TAG) at codon 176. Because the open reading frame of the S gene is completely overlapped by the polymerase gene, mutations in the S gene may affect the polymerase gene. Based on this case, this study suggests that the observed frame-shift mutation in the S gene might affect the polymeraseprotein and induce prompt suppression of viral replication. (C) 2002 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:01:15