Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein
Autore:
Blanco-Vaca, F; Escola-Gil, JC; Martin-Campos, JM; Julve, J;
Indirizzi:
Hosp Santa Cruz & San Pablo, Serv Bioquim, E-08025 Barcelona, Spain Hosp Santa Cruz & San Pablo Barcelona Spain E-08025 025 Barcelona, Spain Hosp Santa Cruz & San Pablo, Inst Recerca, E-08025 Barcelona, Spain Hosp Santa Cruz & San Pablo Barcelona Spain E-08025 025 Barcelona, Spain Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, E-08193 Barcelona, SpainUniv Autonoma Barcelona Barcelona Spain E-08193 E-08193 Barcelona, Spain
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 11, volume: 42, anno: 2001,
pagine: 1727 - 1739
SICI:
0022-2275(200111)42:11<1727:ROAILM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-A-II; HIGH-DENSITY-LIPOPROTEINS; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; VERY-LOW-DENSITY; ESTER TRANSFER PROTEIN; FAMILIAL COMBINED HYPERLIPIDEMIA; DIABETES-SUSCEPTIBILITY GENES; HUMAN-PLASMA-LIPOPROTEINS; CORONARY-ARTERY DISEASE; APOPROTEIN-AII GENE;
Keywords:
apoA-I; apoB; HDL; hyperlipidemia; hypertriglyceridemia; insulin resistance; triglycerides; type 2 diabetes; VLDI;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
113
Recensione:
Indirizzi per estratti:
Indirizzo: Blanco-Vaca, F Hosp Santa Cruz & San Pablo, Serv Bioquim, Antoni M Claret 167, E-08025 Barcelona, Spain Hosp Santa Cruz & San Pablo Antoni M Claret 167 Barcelona Spain E-08025
Citazione:
F. Blanco-Vaca et al., "Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein", J LIPID RES, 42(11), 2001, pp. 1727-1739

Abstract

Our understanding of apolipoprotein A-II (apoA-II) physiology is much morelimited than that of apoA-I. However, important and rather surprising advances have been produced, mainly through analysis of genetically modified mice. These results reveal a positive association of apoA-II with FFA and VLDL triglyceride plasma concentrations; however, whether this is due to increased V-LDL synthesis or to decreased VLDL catabolism remains a matter of controversy. As apoA-II-deficient mice present a phenotype of insulin hypersensitivity, a function of apoA-II in regulating FFA metabolism seems likely. Studies of human beings have shown the apoA-II locus to be a determinant of FFA plasma levels, and several genome-wide searches of different populations with type 2 diabetes have found linkage to an apoA-II intragenic marker, making apoA-II an attractive candidate gene for this disease. The increased concentration of apoB-containing lipoproteins present in apoA-II transgenic mice explains, in part, why these animals present increased atherosclerosis susceptibility. In addition, apoA-II transgenic mice also present impairment of two major HDL antiatherogenic functions: reverse cholesterol transport and protection of LDL oxidative modification. The apoA-II locus has also been suggested as an important genetic determinant of HDL cholesterol concentration, even though there is a major species-specific difference between the effects of mouse and human apoA-II. As antagonizing apoA-I antiatherogenic actions can hardly be considered die apoA-II function in HDL, this remains a topic for future investigations. We suggest that the existence ofapoA-II or apoA-I in HDL could be an important signal for specific interaction with HDL receptors such as cubilin or heat shock protein 60.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:25:25