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Titolo:
Estrogen restores cellular immunity in injured male mice via suppression of interleukin-6 production
Autore:
Messingham, KAN; Heinrich, SA; Kovacs, EJ;
Indirizzi:
Loyola Univ, Med Ctr, Dept Cell Biol Neurobiol & Anat, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 Neurobiol & Anat, Maywood, IL 60153 USA Loyola Univ, Med Ctr, Burn & Shock Trauma Inst, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 Shock Trauma Inst, Maywood, IL 60153 USA Loyola Univ, Med Ctr, Alcohol Res Program, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 cohol Res Program, Maywood, IL 60153 USA Loyola Univ, Med Ctr, Dept Surg, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 ed Ctr, Dept Surg, Maywood, IL 60153 USA Loyola Univ, Med Ctr, Immunol & Aging Program, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 l & Aging Program, Maywood, IL 60153 USA
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 6, volume: 70, anno: 2001,
pagine: 887 - 895
SICI:
0741-5400(200112)70:6<887:ERCIII>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE ETHANOL EXPOSURE; FACTOR-KAPPA-B; THERMAL-INJURY; TRAUMA-HEMORRHAGE; MEDIATED-IMMUNITY; GONADAL-STEROIDS; BURN PATIENTS; ACUTE-PHASE; TGF-BETA; RESPONSES;
Keywords:
cytokine; NF-kappa B; monocyte/macrophage; hormone; ethanol; burn;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Kovacs, EJ Loyola Univ, Med Ctr, Dept Cell Biol Neurobiol & Anat, Bldg 110,Room 4221,2160 S 1st Ave, Maywood, IL 60153 USA Loyola Univ Bldg 110,Room 4221,2160 S 1st Ave Maywood IL USA 60153
Citazione:
K.A.N. Messingham et al., "Estrogen restores cellular immunity in injured male mice via suppression of interleukin-6 production", J LEUK BIOL, 70(6), 2001, pp. 887-895

Abstract

This study examined whether estrogen treatment can improve immunity in male mice after combined ethanol and burn injuries. 17 beta -Estradiol [estrogen, given subcutaneously (s.c.)] or oil (control) was administered at 30 min and 24 h postinjury. At 48 h postinjury, ethanol/burn-injured mice demonstrated significant suppression of cellular immunity. Estrogen treatment restored the delayed-type hypersensitivity (P<0.01) and splenocyte-proliferative (P<0.05) responses, reduced macrophage interleukin-6 (IL-6) (P<0.05), and increased survival after bacterial challenge (P<0.01). In vitro neutralization of IL-6, combined with macrophage supernatant experiments, confirmed that the beneficial effects of estrogen treatment were mediated through modulation of macrophage IL-6 production. Moreover, estrogen treatment resulted in a decrease in splenic nuclear factor-kappaB (NF-kappaB) activation in injured mice. There were no changes in cellular NF-kappaB or I kappaB alphaprotein expression or I kappaB alpha phosphorylation at serine 32. Taken together, these studies suggest that estrogen treatment of injured male miceimproves cellular immunity through direct modulation of NF-kappaB activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 18:06:35