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Titolo:
Acute and chronic neutropenias. What is new?
Autore:
Palmblad, J; Papadaki, HA; Eliopoulos, G;
Indirizzi:
Huddinge Univ Hosp, Karolinska Inst, Dept Med, Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden a Inst, Dept Med, Stockholm, Sweden Huddinge Univ Hosp, Karolinska Inst, Dept Hematol, Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden st, Dept Hematol, Stockholm, Sweden Univ Crete, Sch Med, Dept Hematol, Iraklion, Greece Univ Crete Iraklion Greece ete, Sch Med, Dept Hematol, Iraklion, Greece
Titolo Testata:
JOURNAL OF INTERNAL MEDICINE
fascicolo: 6, volume: 250, anno: 2001,
pagine: 476 - 491
SICI:
0954-6820(200112)250:6<476:AACNWI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE CONGENITAL NEUTROPENIA; CHRONIC IDIOPATHIC NEUTROPENIA; COLONY-STIMULATING-FACTOR; ACUTE MYELOID-LEUKEMIA; CLOZAPINE-INDUCED AGRANULOCYTOSIS; GRANULAR LYMPHOCYTE LEUKEMIA; DRUG-INDUCED AGRANULOCYTOSIS; SHWACHMAN-DIAMOND-SYNDROME; STEM-CELL TRANSPLANTATION; G-CSF;
Keywords:
adverse drug reactions; agranulocytosis; large granular lymphocytosis; myeloid growth factors; neutropenia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Palmblad, J Huddinge Univ Hosp, Dept Med M54, SE-14186 Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden SE-14186 ockholm, Sweden
Citazione:
J. Palmblad et al., "Acute and chronic neutropenias. What is new?", J INTERN M, 250(6), 2001, pp. 476-491

Abstract

Recently, some of the mechanisms and consequences in the severe chronic neutropenias (e.g. the neutrophil elastase gene mutations and the risk to progress to myelodysplasia and acute leukaemia) and in drug-induced agranulocytosis (e.g. the apoptosis-inducing ability of metabolites of clozapine) have been elucidated, and new aspects of autoimmune and the large granular lymphocyte syndrome were described (e.g. aberrant elaboration of Fas-ligand causing neutrophil apoptosis). Investigations of the mild to moderate chronicneutropenias have shown the significance of interactions between the myeloid development and the immune network (e.g. relations to immunoglobulin aberrations). Granulocyte-colony stimulation factor (G-CSF) is Widely used in patients with severe chronic neutropenia, however, its use in other conditions is mostly based on anecdotal evidence. In addition, immune modulating regimens, such as metothrexate, ciclosporine and monoclonal antibodies, are increasingly employed for the autoimmune neutropenias.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:15:49