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Titolo:
Transforming growth factor-beta has contrasting effects in the presence orabsence of exogenous interleukin-12 on the in vitro activation of cells that transfer experimental autoimmune thyroiditis
Autore:
Fondal, W; Sampson, C; Sharp, GC; Braley-Mullen, H;
Indirizzi:
Univ Missouri, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65212 USA Univ Missouri Columbia MO USA 65212 iol & Immunol, Columbia, MO 65212 USA Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65212 USA Univ Missouri Columbia MO USA 65212 Internal Med, Columbia, MO 65212 USA Univ Missouri, Sch Med, Dept Pathol, Columbia, MO 65212 USA Univ MissouriColumbia MO USA 65212 , Dept Pathol, Columbia, MO 65212 USA VA Res Serv, Columbia, MO 65212 USA VA Res Serv Columbia MO USA 65212VA Res Serv, Columbia, MO 65212 USA
Titolo Testata:
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
fascicolo: 11, volume: 21, anno: 2001,
pagine: 971 - 980
SICI:
1079-9907(200111)21:11<971:TGFHCE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; REGULATORY T-CELLS; TGF-BETA; IFN-GAMMA; B-CELLS; INTERFERON-GAMMA; IMMUNE-RESPONSES; DOWN-REGULATION; HOST-DEFENSE; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Braley-Mullen, H Univ Missouri, Sch Med, Dept Med, Div Immunol, Room M450 Med Sci, Columbia, MO 65212 USA Univ Missouri Room M450 Med Sci Columbia MOUSA 65212 USA
Citazione:
W. Fondal et al., "Transforming growth factor-beta has contrasting effects in the presence orabsence of exogenous interleukin-12 on the in vitro activation of cells that transfer experimental autoimmune thyroiditis", J INTERF CY, 21(11), 2001, pp. 971-980

Abstract

Mouse thyroglobulin (MuTg)-sensitized spleen cells activated in vitro withMuTg induce experimental autoimmune thyroiditis (EAT) in recipient mice with a thyroid infiltrate consisting primarily of lymphocytes. A more severe and histologically distinct granulomatous form of EAT (G-EAT) is induced when donor cells are activated with MuTg together with anti-interferon-gamma (IFN-gamma), anti-interleukin-2 receptor (IL-2R) monoclonal antibody (mAb),and IL-12. Transforming growth factor-beta (TGF-beta) is a multifunctionalcytokine that can both suppress and exacerbate autoimmune diseases and often has inhibitory effects on lymphocytes. To determine if TGF-beta could modulate the in vitro activation of effector cells for G-EAT, TGF-beta was added to cultures of MuTg-sensitized donor spleen cells together with MuTg. Cells activated in the presence of 2 ng/ml TGF-beta induced moderately severe G-EAT in recipient mice. G-EAT induced by cells activated in the presenceof TGF-beta was histologically similar but less severe than the G-EAT induced by cells activated in the presence of IL-12. IL-12 and TGF-beta modulate the activation of G-EAT effector cells by distinct mechanisms, as cells activated by TGF-beta could induce G-EAT in the presence of anti-IL-12, and TGF-beta inhibited the effects of IL-12 on EAT effector cells. TGF-beta exerted its activity during the first 24 h of the 72-h culture, whereas IL-12 functioned primarily during the final 24 h of culture. These results indicate that thyroid lesions with granulomatous histopathology can be induced byboth IL-12-dependent and IL-12-independent mechanisms, and TGF-beta can exert both positive and negative effects on the effector cells for G-EAT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:00:02