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Titolo:
Induction of cytotoxic CD8(+)CD56(+) T cells from human thymocytes by interleukin-15
Autore:
Thulesen, S; Nissen, MH; Odum, N; Ropke, C;
Indirizzi:
Univ Copenhagen, Panum Inst, Inst Med Anat, Dept A,Sect A, DK-2200 Copenhagen N, Denmark Univ Copenhagen Copenhagen Denmark N ct A, DK-2200 Copenhagen N, Denmark Univ Copenhagen, Panum Inst, Inst Med Microbiol & Immunol, Cell Cybernet Lab, DK-2200 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2200 , DK-2200 Copenhagen, Denmark
Titolo Testata:
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
fascicolo: 11, volume: 21, anno: 2001,
pagine: 905 - 911
SICI:
1079-9907(200111)21:11<905:IOCCTC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPARIN-BINDING DOMAIN; IL-2 RECEPTOR; BETA-CHAIN; ADHESION MOLECULES; GROWTH-FACTOR; KILLER-CELLS; ALPHA-CHAIN; NK CELLS; EXPRESSION; CYTOKINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Thulesen, S Univ Copenhagen, Panum Inst, Inst Med Anat, Dept A,Sect A, Blegdamsvej 3C,DK-2200 Copenhagen N, Denmark Univ Copenhagen Blegdamsvej 3C Copenhagen Denmark N , Denmark
Citazione:
S. Thulesen et al., "Induction of cytotoxic CD8(+)CD56(+) T cells from human thymocytes by interleukin-15", J INTERF CY, 21(11), 2001, pp. 905-911

Abstract

CD8(+)CD56(+) cells isolated from human peripheral blood lymphocytes have been shown recently to represent a population of cytotoxic active T cells. However, it is not known if these cells are intrathymically or extrathymically developed or how these cells are influenced by growth factors. In the present study, we investigated the effects of interleukin-2 (IL-2) and IL-15on human thymocytes with respect to development of CD8(+)CD56(+) T cells. Freshly isolated thymocytes contain few CD8(+)CD56(+) cells, but the numberof these cells increases significantly when thymocytes are grown in the presences of IL-15 or IL-2. However, IL-15 induced a significantly higher fraction of CD8(+)CD56(+) cells compared with IL-2. Thus, although IL-2 and IL-15 are known to have a number of redundant functions, we here demonstrate that IL-15 is superior to IL-2 in inducing CD8(+)CD56(+) T cells from cultures of thymocytes. The majority of the IL-15-grown CD8(+)CD56(+) cells wereCD45R0(+), representing a memory phenotype, and showed high expression of the IL-15R-complex and high numbers of CD69(+) cells. Moreover, cytotoxic activity was confined to this cell population.

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Documento generato il 07/04/20 alle ore 21:22:51