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Titolo:
Gender differences in the timing of arterial wave reflection beyond differences in body height
Autore:
Gatzka, CD; Kingwell, BA; Cameron, JD; Berry, KL; Liang, YL; Dewar, EM; Reid, CM; Jennings, GL; Dart, AM;
Indirizzi:
Baker Med Res Inst, Alfred & Baker Med Unit, Prahran, Vic 3181, Australia Baker Med Res Inst Prahran Vic Australia 3181 rahran, Vic 3181, Australia La Trobe Univ, Melbourne, Vic, Australia La Trobe Univ Melbourne Vic Australia be Univ, Melbourne, Vic, Australia
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 12, volume: 19, anno: 2001,
pagine: 2197 - 2203
SICI:
0263-6352(200112)19:12<2197:GDITTO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR MORTALITY; ESSENTIAL-HYPERTENSION; PRESSURE AUGMENTATION; ELASTIC PROPERTIES; AORTIC STIFFNESS; PULSE PRESSURE; BLOOD-PRESSURE; AGE; POPULATION; CIRCULATION;
Keywords:
arterial wave reflection; pulse wave velocity; gender differences; arterial hypertension; left ventricular structure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Gatzka, CD Alfred Hosp, Alfred & Baker Med Unit, Commercial Rd, Prahran, Vic 3181, Australia Alfred Hosp Commercial Rd Prahran Vic Australia 3181 Australia
Citazione:
C.D. Gatzka et al., "Gender differences in the timing of arterial wave reflection beyond differences in body height", J HYPERTENS, 19(12), 2001, pp. 2197-2203

Abstract

Objectives The timing of arterial wave reflection affects the shape of thearterial waveform and thus is a major determinant of pulse pressure. This study assessed differences in wave reflection between genders beyond the effect of body height. Methods From 1123 elderly (aged 71 +/- 5 years) currently untreated hypertensives, we selected 104 pairs of men and women with identical body height (average 164 +/- 4 cm). All subjects underwent echocardiography, including measurement of aortic arch expansion, automated blood pressure measurements, measurement of ascending aortic blood flow and simultaneous carotid artery tonometry. Results Women had higher pulse (80 +/- 17 versus 74 +/- 17 mmHg, P < 0.05)and lower diastolic pressure (79 +/- 11 versus 82 +/- 10 mmHg, P < 0.05). Whilst heart rate was similar, women had a longer time to the systolic peak(210 +/- 28 versus 199 +/- 34 ms, P < 0.01) and a longer ejection time (304 +/- 21 versus 299 +/- 25 ms, P < 0.001). Wave reflection occurred earlierin women (time between maxima 116 +/- 55 versus 132 +/- 47 ms, P < 0.05) and augmentation index was higher (36 +/- 11 versus 28 +/- 12%, P < 0.001). Aortic diameter was smaller in women and the aortic arch was stiffer (median E-p 386 versus 302 kN/m(2), P < 0.05). Hence, systemic arterial compliance was less in women (0.8 +/- 0.2 versus 1.0 +/- 0.3 ml/mmHg). Conclusions We conclude that elderly hypertensive men and women have a different timing of both left ventricular ejection and arterial wave reflection when both genders are matched for body height Women have smaller and stiffer blood vessels resulting in an earlier return of the reflected wave, which is likely due to an increased pulse wave velocity in women. J Hypertens 19:2197-2203 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:50:30