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Titolo:
The alpha(2)-adrenergic receptors in hypertension and heart failure: experimental and clinical studies
Autore:
Gavras, I; Manolis, AJ; Gavras, H;
Indirizzi:
Boston Univ, Sch Med, Hypertens & Atherosclerosis Sect, Dept Med, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 osis Sect, Dept Med, Boston, MA 02118 USA
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 12, volume: 19, anno: 2001,
pagine: 2115 - 2124
SICI:
0263-6352(200112)19:12<2115:TARIHA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; SYMPATHETIC NERVOUS-SYSTEM; NUCLEUS TRACTUS SOLITARII; SALT-INDUCED HYPERTENSION; BLOOD-PRESSURE; ALPHA-ADRENOCEPTORS; HYPERTONIC SALINE; ALPHA(2B)-ADRENERGIC RECEPTOR; SODIUM-CHLORIDE; RATS;
Keywords:
alpha(2)-adrenoceptor subtypes; salt-induced hypertension; sympathoinhibition; sympathoexcitation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Gavras, H Boston Univ, Sch Med, Hypertens & Atherosclerosis Sect, Dept Med, 715 Albany St, Boston, MA 02118 USA Boston Univ 715 Albany St Boston MA USA 02118 ston, MA 02118 USA
Citazione:
I. Gavras et al., "The alpha(2)-adrenergic receptors in hypertension and heart failure: experimental and clinical studies", J HYPERTENS, 19(12), 2001, pp. 2115-2124

Abstract

This is a brief overview of experimental and clinical studies exploring the hemodynamic functions of the alpha (2A) and alpha (2B) adrenergic receptor (AR) subtypes in animals submitted to genetic manipulations or gene treatment, as well as the clinical effects of central sympathetic suppression with the alpha (2)-AR agonist clonidine in patients with ischemic heart disease and/or heart failure. The animal experiments have led us to conclude that the sympathetic outflow is regulated by activation of the presynaptic alpha (2A)-AR subtype, which is the predominant alpha (2)-AR subtype in the central nervous system and exerts a sympathoinhibitory (hypotensive) action; on the contrary, activation of the central alpha (2B)-AR elicits a sympathoexcitatory response (such as seen in salt-induced hypertension, which requires functionally intact alpha (2B)-AR). Since there are no selective pharmacologic agents yet capable of discriminating among alpha (2)-AR subtypes, clinical studies utilize clonidine, the central sympathetic suppressant effect of which has been used for 35 years to treat hypertension. In small clinical trials, clonidine was used successfully for treatment of acute or chronic heart failure, acute myocardial infarct or hypertensive cardiomyopathy with subclinical diastolic dysfunction. We speculate that future development of agents capable of selectively activating the alpha (2A)-AR or blockingthe alpha (2B)-AR may further improve our capability to treat hypertension, ischemic heart disease and heart failure. J Hypertens 19:2115-2124 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:27:02