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Titolo:
Replacement therapy with hydrocortisone in catecholamine-dependent septic shock
Autore:
Annane, D;
Indirizzi:
Univ Paris 05, Fac Med Paris Ouest, Hop Raymond Poincare, Serv Reanimat Med, F-92380 Garches, France Univ Paris 05 Garches France F-92380 animat Med, F-92380 Garches, France
Titolo Testata:
JOURNAL OF ENDOTOXIN RESEARCH
fascicolo: 4, volume: 7, anno: 2001,
pagine: 305 - 309
SICI:
0968-0519(2001)7:4<305:RTWHIC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; GLUCOCORTICOID RECEPTOR; NEGATIVE REGULATION; ENDOTOXIN; SEPSIS; RESPONSES; RATS; LIPOPOLYSACCHARIDE; IMMUNOSUPPRESSION; HYPERCORTISOLEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Annane, D Univ Paris 05, Fac Med Paris Ouest, Hop Raymond Poincare, Serv Reanimat Med, F-92380 Garches, France Univ Paris 05 Garches France F-92380, F-92380 Garches, France
Citazione:
D. Annane, "Replacement therapy with hydrocortisone in catecholamine-dependent septic shock", J ENDOTOX R, 7(4), 2001, pp. 305-309

Abstract

Septic shock is one of the leading causes of death in intensive care unitsworld-wide. Scientists have made great improvements in understanding mechanisms of inflammation. and the sequence of activation of the various pro- and anti-inflammatory markers is now well known. In contrast. physicians have failed to improve survival from septic shock despite the development of specific targets at various points in the cytokine cascade considered to have a key role in host survival in sepsis. Corticosteroids were among the first anti-inflammatory drugs to be tested in large randomized controlled trials. These trials showed that patients with septic shock did not benefit from a short course of large doses of steroids. More recent findings highlighting the role of the integrity of the hypothalamic-pituitary-adrenal axis torespond appropriately to a septic insult, have led to a re-appraisal of the use of steroids in septic shock. Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis. These trials strongly suggest that this replacement therapy reduces the morbidity of septic shock and may favorably affect survival from septic shock.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:44:44