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Titolo:
Synaptic patterns of thalamocortical afferents in mouse barrels at postnatal day 11
Autore:
Lev, DL; Weinfeld, EB; White, EL;
Indirizzi:
Ben Gurion Univ Negev, Fac Hlth Sci, Dept Morphol, Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel ept Morphol, Beer Sheva, Israel Ben Gurion Univ Negev, Zlotowski Ctr Neurosci, Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel tr Neurosci, Beer Sheva, Israel
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 1, volume: 442, anno: 2002,
pagine: 63 - 77
SICI:
0021-9967(20020101)442:1<63:SPOTAI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASEOLUS-VULGARIS-LEUKOAGGLUTININ; BIOTINYLATED DEXTRAN-AMINE; RAT SOMATOSENSORY CORTEX; SOMATIC SENSORY CORTEX; MEDIAL NUCLEUS VPM; LAYER-IV; SML CORTEX; CORTICOTHALAMIC PROJECTIONS; GENICULOCORTICAL AXONS; VIBRISSAL INFORMATION;
Keywords:
somatosensory cortex; thalamus; three-dimensional reconstruction; development; synapse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: White, EL Ben Gurion Univ Negev, Fac Hlth Sci, Dept Morphol, POB 653, BeerSheva, Israel Ben Gurion Univ Negev POB 653 Beer Sheva Israel Sheva, Israel
Citazione:
D.L. Lev et al., "Synaptic patterns of thalamocortical afferents in mouse barrels at postnatal day 11", J COMP NEUR, 442(1), 2002, pp. 63-77

Abstract

This study focuses on the synaptic output patterns of thalamocortical axons in mouse barrel cortex at postnatal day (P) 11. Axons were labeled by biotinylated dextran amine transported anterogradely following injection in vivo into the ventrobasal thalamus. Labeled axons in the posteromedial barrelsubfield were examined by light and electron microscopy and then reconstructed in three dimensions to assess the spatial distribution of their synapses. Thalamocortical axons form asymmetrical synapses, both at varicosities and along cylindrical portions of the axons; usually, only one synapse occurs per site, contrasting with the case in the adult, in which multiple synapses are typical. At P11, varicosities without synapses are common. As in adult barrels, approximately 80% of synapses formed by thalamocortical axonsare with dendritic spines; 20% are with dendritic shafts. The similarity in the distribution of thalamocortical synapses onto spines vs. dendrites indeveloping and mature barrels indicates that adult synaptic patterns already are specified at a very early stage of thalamocortical synaptogenesis. (C) 2002 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/06/20 alle ore 10:44:15