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Titolo:
Occurrence of glutamate receptor subunit 1-containing aggresome-like structures during normal development of rat spinal cord interneurons
Autore:
Serrando, M; Casanovas, A; Esquerda, JE;
Indirizzi:
Univ Lleida, Fac Med, Dept Ciencies Med Basiques, Unitat Neurobiol Cellular, E-25198 Lleida, Spain Univ Lleida Lleida Spain E-25198 urobiol Cellular, E-25198 Lleida, Spain
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 1, volume: 442, anno: 2002,
pagine: 23 - 34
SICI:
0021-9967(20020101)442:1<23:OOGRS1>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOPLASMIC INCLUSION; PROTEIN AGGREGATION; STIGMOID BODY; HEAT-SHOCK; LOCALIZATION; ASSOCIATION; PROTEASOME; DISEASE; BODIES; BRAIN;
Keywords:
AMPA; protein aggregation; inclusion bodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Esquerda, JE Univ Lleida, Fac Med, Dept Ciencies Med Basiques, Unitat Neurobiol Cellular, Rovira Roure 44, E-25198 Lleida, Spain Univ Lleida Rovira Roure 44 Lleida Spain E-25198 eida, Spain
Citazione:
M. Serrando et al., "Occurrence of glutamate receptor subunit 1-containing aggresome-like structures during normal development of rat spinal cord interneurons", J COMP NEUR, 442(1), 2002, pp. 23-34

Abstract

During a developmental study of the expression of alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) -type glutamate receptor subunits in rat spinal cord, we observed the existence of cytoplasmic inclusion bodies with positive immunoreactivity to glutamate receptor subunit 1 (GluR1) but not to other glutamate receptor subunits. GluR1-positive bodies have a diameter of between 1 and 3 Lm and can be seen widely distributed throughout spinal cord gray matter, with the exception of the ventral horn region. They transiently appear within a definite developmental time-period between embryonic day 19 and postnatal day 17 and are only associated with neuronal cells. Ultrastructural analysis revealed that these inclusions were located adjacent to the nucleus and consisted of amorphous material without any limiting membrane. Immunocytochemical analysis revealed that the inclusions displayed positive immunoreactivity to ubiquitin, HSP70, and 20S proteasome. Allthese data indicate that GluR1-containing inclusions display all the ultrastructural and immunocytochemical characteristics of the recently describedstructure, which have been given the name aggresomes. Further studies are needed to determine the biological significance of these normally occurringaggresome-like inclusions, because aggresomes are usually considered in a pathologic context. (C) 2002 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/12/19 alle ore 15:30:09