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Titolo:
PRESERVATION OF PIG-LIVER ALLOGRAFTS AFTER WARM ISCHEMIA - NORMOTHERMIC PERFUSION VERSUS COLD-STORAGE
Autore:
HELLINGER A; FIEGEN R; LANGE R; RAUEN U; SCHMIDT U; HIRCHE H; KAISER S; DEGROOT H; ERHARD J; EIGLER FW;
Indirizzi:
UNIV ESSEN GESAMTHSCH,ABT ALLGEMEINE CHIRURG,HUFELANDSTR 55 D-45122 ESSEN GERMANY
Titolo Testata:
Langenbecks Archiv fur Chirurgie
fascicolo: 4, volume: 382, anno: 1997,
pagine: 175 - 184
SICI:
0023-8236(1997)382:4<175:POPAAW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-BEATING DONORS; RAT-LIVER; TRANSPLANTATION; INJURY;
Keywords:
LIVER TRANSPLANTATION; WARM ISCHEMIA; ORGAN PRESERVATION; COLD STORAGE; NORMOTHERMIC PERFUSION; REPERFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A. Hellinger et al., "PRESERVATION OF PIG-LIVER ALLOGRAFTS AFTER WARM ISCHEMIA - NORMOTHERMIC PERFUSION VERSUS COLD-STORAGE", Langenbecks Archiv fur Chirurgie, 382(4), 1997, pp. 175-184

Abstract

Warm ischemia is known to induce substantial damage to the liver parenchyma. With respect to clinical liver transplantation, the tolerance of the liver to warm ischemia and the preservation of these organs have not been studied in detail. In isolated reperfused pig livers we proceeded according to the following concept: Livers were subjected to 1 or 3 h of warm ischemia. Subsequently, these organs were preserved by either normothermic perfusion or cold storage (histidine-tryptophan-alpha-ketoglutarate, HTK) for 3 h each. After storage, liver function was assessed in a reperfusion circuit for another 3 h. Parameters under evaluation were bile flow, perfusion flow, oxygen consumption, enzyme release into the perfusate (creatine kinase, glutamic oxaloacetic transaminase (GOT), lactic dehydrogenase, and glutamic pyruvic transaminase), and histomorphology. Damage to the liver was lowest after warm ischemia of 1 h. The results after cold storage were superior to those after normothermic perfusion (GOT: 3.2 +/- 0.3 and 2.6 +/- 0.2 U/g liver; cumulative bile production: 14.7 +/- 2.1 and 9.4 +/- 1 ml, respectively; P < 0.05). In contrast, we found substantial damage at the end ofreperfusion in livers undergoing 3 h of warm ischemia under both preservation techniques with severe hepatocellular pyknoses and essentially altered nonparenchymal cells. The results suggest that pig livers undergoing 1 h of warm ischemia and cold storage for 3 h with HTK solution may lead to functioning after transplantation.

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Documento generato il 04/04/20 alle ore 12:07:06