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Titolo:
Distribution of alpha-neoendorphin immunoreactivity in the diencephalon and the brainstem of the dog
Autore:
Pesini, P; Pego-Reigosa, R; Tramu, G; Covenas, R;
Indirizzi:
Univ Santiago, Fac Vet, Dept Anat, Lugo 27002, Spain Univ Santiago Lugo Spain 27002 go, Fac Vet, Dept Anat, Lugo 27002, Spain Univ Bordeaux 1, CNRS, URA 339, Neurocytochim Fonct Lab, F-33405 Talence, France Univ Bordeaux 1 Talence France F-33405 onct Lab, F-33405 Talence, France Inst Neurociencias Castilla & Leon, Lab Neuroanat Sistemas Peptiderg, Salamanca, Spain Inst Neurociencias Castilla & Leon Salamanca Spain rg, Salamanca, Spain
Titolo Testata:
JOURNAL OF CHEMICAL NEUROANATOMY
fascicolo: 4, volume: 22, anno: 2001,
pagine: 251 - 262
SICI:
0891-0618(200111)22:4<251:DOAIIT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; BETA-NEO-ENDORPHIN; RAT-BRAIN; DYNORPHIN-A; IMMUNOHISTOCHEMICAL DISTRIBUTION; ENKEPHALIN SYSTEMS; MESSENGER-RNA; SPINAL-CORD; STEM; PEPTIDES;
Keywords:
brain; endogenous opioids; immunohistochemistry; neuropeptides; hypothalamus; thalamus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Pesini, P Univ Santiago, Fac Vet, Dept Anat, Lugo 27002, Spain Univ Santiago Lugo Spain 27002 t, Dept Anat, Lugo 27002, Spain
Citazione:
P. Pesini et al., "Distribution of alpha-neoendorphin immunoreactivity in the diencephalon and the brainstem of the dog", J CHEM NEUR, 22(4), 2001, pp. 251-262

Abstract

Alpha-neoendorphin (alpha -NE) is an opiate decapeptide derived from the prodynorphin protein. Its anatomical distribution in the brain of mammals other than the rat. particularly in carnivores. is less well known than for other opiate peptides. In the present work, we have charted the distributionof a-NE immunoreactive fibers and perikarya in the diencephalon and the brainstem of the dog. The highest densities of labeled fibers were found in the substantia nigra and in patches within the nucleus of the solitary tract. Moderate densities appeared in the arcuate nucleus (Ar), median eminence,entopeduncular nucleus, ventral tegmental area, retrorubral area, periaqueductal central gray, interpeduncular nucleus and lateral parabrachial nucleus. Groups of numerous labeled perikarya were localized in the magnocellular hypothalamic nuclei, Ar and in the central superior and incertus nuclei in the metencephalon. Moreover. less densely packed fibers and cells appeared widely distributed throughout many nuclei in the region studied. These results are discussed with regard to the pattern described in other species. In addition. the present results were compared with the distribution of met-enkephalin immunoreactivity in the diencephalon and the brainstem of the dog that we have recently described. Although the distributions of these twopeptides overlap in many areas, the existence of numerous differences suggest that they form separate opiate systems in the dog. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 04/12/20 alle ore 09:26:32