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Titolo:
Role of id family proteins in growth control
Autore:
Yokota, Y; Mori, S;
Indirizzi:
Fukui Med Univ, Dept Biochem, Matsuoka, Fukui 9101193, Japan Fukui Med Univ Matsuoka Fukui Japan 9101193 atsuoka, Fukui 9101193, Japan
Titolo Testata:
JOURNAL OF CELLULAR PHYSIOLOGY
fascicolo: 1, volume: 190, anno: 2002,
pagine: 21 - 28
SICI:
0021-9541(200201)190:1<21:ROIFPI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOOP-HELIX PROTEIN; SENESCENT HUMAN FIBROBLASTS; CELL-CYCLE ARREST; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTORS; GENE-EXPRESSION; REPLICATIVE SENESCENCE; HUMAN NEUROBLASTOMAS; NEGATIVE REGULATOR; DNA-BINDING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Yokota, Y Fukui Med Univ, Dept Biochem, 23-3 Shimoaizuki, Matsuoka, Fukui 9101193, Japan Fukui Med Univ 23-3 Shimoaizuki Matsuoka Fukui Japan 9101193pan
Citazione:
Y. Yokota e S. Mori, "Role of id family proteins in growth control", J CELL PHYS, 190(1), 2002, pp. 21-28

Abstract

Id proteins (inhibitors of DNA binding/differentiation) are negative regulators of basic helix-loop-helix (bHLH) type transcription factors, which promote the differentiation of various cell types. In addition to their "classical" ability to inhibit cell differentiation, they are able to stimulate cell cycle progression. These facts suggest that Id proteins play a role inkeeping precursor cells immature and in expanding the cell population sizeduring development. In vitro as well as in vivo analyses in the last several years have shown that Id proteins have more complex activities; they induce apoptosis or function as survival factors, depending on the cell context. Furthermore, dysregulated expression of Id proteins has been reported inseveral human tumors and seems to be related to the malignant character oftumors. Here, we summarize and discuss the biological activities of Id proteins from the standpoint of cell growth control. (C) 2002 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 13:58:30