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Titolo:
Roads to polyploidy: The megakaryocyte example
Autore:
Ravid, K; Lu, J; Zimmet, JM; Jones, MR;
Indirizzi:
Boston Univ, Sch Med, Dept Biochem, Whitaker Cardiovasc Inst, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 ker Cardiovasc Inst, Boston, MA 02118 USA
Titolo Testata:
JOURNAL OF CELLULAR PHYSIOLOGY
fascicolo: 1, volume: 190, anno: 2002,
pagine: 7 - 20
SICI:
0021-9541(200201)190:1<7:RTPTME>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINDLE POLE BODY; HUMAN CELL-CYCLE; CYCLOSOME/ANAPHASE-PROMOTING COMPLEX; XENOPUS EGG EXTRACTS; KINASE INHIBITOR P21; DNA-REPLICATION; FISSION YEAST; S-PHASE; PROTEIN-KINASE; GENE-EXPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Ravid, K Boston Univ, Sch Med, Dept Biochem, Whitaker Cardiovasc Inst, K225,715 Albany St, Boston, MA 02118 USA Boston Univ K225,715 Albany St BostonMA USA 02118 , MA 02118 USA
Citazione:
K. Ravid et al., "Roads to polyploidy: The megakaryocyte example", J CELL PHYS, 190(1), 2002, pp. 7-20

Abstract

Polyploidy, recognized by multiple copies of the haploid chromosome number, has been described in plants, insects, and in mammalian cells such as, the platelet precursors, the megakaryocytes. Several of these cell types reach high ploidy via a different cell cycle. Megakaryocytes undergo an endomitotic cell cycle, which consists of an S phase interrupted by a gap, during which the cells enter mitosis but skip anaphase B and cytokinesis. Here, wereview the mechanisms that lead to this cell cycle and to polyploidy in megakaryocytes, while also comparing them to those described for other systems in which high ploidy is achieved. Overall, polyploidy is associated with an orchestrated change in expression of several genes, of which, some may be a result of high ploidy and hence a determinant of a new cell physiology,while others are inducers of polyploidization. Future studies will aim to further explore these two groups of genes. (C) 2002 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 08:05:03