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Titolo:
Dopamine transporter density and novelty seeking among alcoholics
Autore:
Laine, TPJ; Ahonen, A; Rasanen, P; Tiihonen, J;
Indirizzi:
Oulu Univ, Dept Psychiat, FIN-90220 Oulu, Finland Oulu Univ Oulu FinlandFIN-90220 Dept Psychiat, FIN-90220 Oulu, Finland Oulu Univ, Dept Nucl Med, FIN-90220 Oulu, Finland Oulu Univ Oulu FinlandFIN-90220 Dept Nucl Med, FIN-90220 Oulu, Finland Univ Kuopio, Dept Forens Psychiat, FIN-70210 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70210 Psychiat, FIN-70210 Kuopio, Finland
Titolo Testata:
JOURNAL OF ADDICTIVE DISEASES
fascicolo: 4, volume: 20, anno: 2001,
pagine: 91 - 96
SICI:
1055-0887(2001)20:4<91:DTDANS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
REUPTAKE SITE DENSITIES; D3 RECEPTOR GENE; PERSONALITY-TRAITS; SOCIAL PHOBIA; ASSOCIATION; POLYMORPHISMS; D-2;
Keywords:
dopamine; novelty seeking; personality traits; alcoholism; neuroimaging; tropanes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Laine, TPJ Oulu Univ Hosp, Dept Psychiat, FIN-90220 Oulu, Finland Oulu Univ Hosp Oulu Finland FIN-90220 FIN-90220 Oulu, Finland
Citazione:
T.P.J. Laine et al., "Dopamine transporter density and novelty seeking among alcoholics", J ADDICT D, 20(4), 2001, pp. 91-96

Abstract

Objective: The aim of this study was to investigate a putative associationbetween the personality trait of novelty seeking (NS) and dopaminergic neuronal activity in the human brain. Method: We studied the striatal dopamine transporter (DAT) density of 30 (18 early and 12 late-onset) alcoholics and 26 healthy controls with beta -CIT ([I-123]-2-beta -carbomethoxy-3-beta-(4-iodophenyl)-tropane) and SPET (Single Photon Emission Tomography); personality traits were assessed with the Tridimensional Personality Questionnaire (TPQ). Results: DAT density correlated significantly with both NS (r = 0.46, p = 0.011) and age (r = -0.50, p = 0.005) in the alcoholics, generally. NS scores were higher in alcoholics with antisocial personality disorder (p = 0.004) than among other alcoholics. Conclusion: Among alcoholics, NS correlated positively with DAT density, which is in line with Cloninger's theory concerning personality and character. (C) 2001 by The Haworth Press, Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 10:41:37