Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Torsades de pointes associated with high dose levomethadyl acetate (ORLAAM(R))
Autore:
Deamer, RL; Wilson, DR; Clark, DS; Prichard, JG;
Indirizzi:
Ventura Cty Med Ctr, Dept Med Educ, Ventura, CA 93003 USA Ventura Cty Med Ctr Ventura CA USA 93003 Med Educ, Ventura, CA 93003 USA Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ So Calif, Sch Pharm, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 h Pharm, Los Angeles, CA 90089 USA Ventura Cty Med Ctr, Dept Family Practice, Ventura, CA 93003 USA Ventura Cty Med Ctr Ventura CA USA 93003 Practice, Ventura, CA 93003 USA Ventura Cty Med Ctr, Dept Cardiol, Ventura, CA 93003 USA Ventura Cty Med Ctr Ventura CA USA 93003 t Cardiol, Ventura, CA 93003 USA Ventura Cty Med Ctr, Dept Med, Ventura, CA 93003 USA Ventura Cty Med Ctr Ventura CA USA 93003 Dept Med, Ventura, CA 93003 USA
Titolo Testata:
JOURNAL OF ADDICTIVE DISEASES
fascicolo: 4, volume: 20, anno: 2001,
pagine: 7 - 14
SICI:
1055-0887(2001)20:4<7:TDPAWH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DE-POINTES; EFFICACY; GENDER;
Keywords:
drug-induced; arrhythmias; ventricular; females; heroin dependency; opioids; methadone; derivatives; levomethadyl; cocaine; fluoxetine; selective-serotonin reuptake inhibitors; drug metabolites; drug interactions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Deamer, RL Ventura Cty Med Ctr, Dept Med Educ, 3291 Loma Vista Rd, Ventura, CA 93003 USA Ventura Cty Med Ctr 3291 Loma Vista Rd Ventura CA USA 93003 USA
Citazione:
R.L. Deamer et al., "Torsades de pointes associated with high dose levomethadyl acetate (ORLAAM(R))", J ADDICT D, 20(4), 2001, pp. 7-14

Abstract

A patient undergoing management of heroin dependency with high dosages of the long-acting methadone derivative, levomethadyl acetate HCI (LAAM; ORLAAM((R))) developed a prolonged QTc interval and polymorphic QRS complexes onEKG consistent with torsades de pointes (TdP). The patient was taking other drugs known to prolong the QTc interval (fluoxetine and IV cocaine), and those known to antagonize the activity of the P450 enzymes responsible for the metabolism of LAAM and its active metabolite (fluoxetine, cocaine and marijuana). No previous reports have appeared in the literature attributing this adverse event to LAAM therapy; however, five similar cases have been reported to the manufacturer. Animal studies indicate that LAAM and metabolites prolong the action potential duration of myocardial cells. We propose that predisposed patients on high doses of LAAM may be at risk for developing TdP. Patients being treated with LAAM should receive dosages consistent with guidelines and be evaluated for concomitant diseases, interacting drug therapies, and EKG abnormalities. (C) 2001 by The Haworth Press, Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:41:17