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Titolo:
Noradrenaline reduces the stimulatory effect of interleukin-1 alpha on reactive oxygen species production by oyster immunocytes
Autore:
Lacoste, A; Malham, SK; Cueff, A; Poulet, SA;
Indirizzi:
Univ Paris 07, INSU, CNRS, Stn Biol Roscoff, F-29682 Roscoff, France Univ Paris 07 Roscoff France F-29682 ol Roscoff, F-29682 Roscoff, France
Titolo Testata:
INVERTEBRATE BIOLOGY
fascicolo: 4, volume: 120, anno: 2001,
pagine: 358 - 364
SICI:
1077-8306(2001)120:4<358:NRTSEO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUMINOL-DEPENDENT CHEMILUMINESCENCE; MYTILUS-EDULIS; CRASSOSTREA-GIGAS; INVERTEBRATE CYTOKINES; ASTERIAS-FORBESI; MODULATION; HEMOCYTES; IMMUNE; CELLS; CATECHOLAMINES;
Keywords:
catecholamines; cytokines; chemiluminescence; Crassostrea gigas;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Lacoste, A Univ Paris 07, INSU, CNRS, Stn Biol Roscoff, Pl Georges Teissier,BP 74, F-29682 Roscoff, France Univ Paris 07 Pl Georges Teissier,BP 74 Roscoff France F-29682
Citazione:
A. Lacoste et al., "Noradrenaline reduces the stimulatory effect of interleukin-1 alpha on reactive oxygen species production by oyster immunocytes", INVERTEBR B, 120(4), 2001, pp. 358-364

Abstract

A growing body of evidence suggests that interleukin-1 alpha (IL-1 alpha) is present in invertebrates. Both invertebrate and human IL-1 alpha can bind to invertebrate receptors and stimulate invertebrate immune functions. The present study shows that IL-1 alpha increases reactive oxygen species (ROS) production by oyster immunocytes. However, physiological doses of noradrenaline (NA) exert a suppressive effect on IL-1 alpha stimulation in vitro. The beta -adrenoceptor agonist isoproterenol mimicked the effects of NA and the beta -adrenoceptor antagonist propanolol blocked the NA-induced suppression of hemocyte responsiveness to IL-1 alpha. The type IV phosphodiesterase inhibitor rolipram acted in synergy with isoproterenol to reduce hemocyte response to IL-1 alpha and the protein kinase A inhibitor H-89 suppressed the effects of isoproterenol. These results suggest that circulating NA impairs IL-1 alpha -stimulation of oyster hemocyte via a beta -adrenoceptor/cyclic AMP/protein kinase-A signaling pathway. Considering that mollusc immunocytes secrete NA, an autocrine regulatory loop may also modulate the ability of these cells to respond to IL-1 alpha.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:56:08