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Titolo:
Cancer risk in persons receiving prescriptions for paracetamol: A Danish cohort study
Autore:
Friis, S; Nielsen, GL; Mellemkjaer, L; McLaughlin, JK; Thulstrup, AM; Blot, WJ; Lipworth, L; Vilstrup, H; Olsen, JH;
Indirizzi:
Danish Canc Soc, Inst Canc Epidemiol, DK-2100 Copenhagen, Denmark Danish Canc Soc Copenhagen Denmark DK-2100 , DK-2100 Copenhagen, Denmark Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark Aarhus UnivHosp Aarhus Denmark DK-8000 idemiol, DK-8000 Aarhus, Denmark Aalborg Hosp, Aalborg, Denmark Aalborg Hosp Aalborg DenmarkAalborg Hosp, Aalborg, Denmark Aalborg Hosp, Dept Med & Gastroenterol M, Aalborg, Denmark Aalborg Hosp Aalborg Denmark pt Med & Gastroenterol M, Aalborg, Denmark Int Epidemiol Inst, Rockville, MD USA Int Epidemiol Inst Rockville MD USA nt Epidemiol Inst, Rockville, MD USA Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Med Ctr, Dept Med, Nashville,TN USA Vanderbilt Univ Nashville TN USA tr, Med Ctr, Dept Med, Nashville,TN USA Aarhus Univ Hosp, Dept Med Hepatol & Gastroenetrol 5, DK-8000 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 etrol 5, DK-8000 Aarhus, Denmark
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 1, volume: 97, anno: 2002,
pagine: 96 - 101
SICI:
0020-7136(20020101)97:1<96:CRIPRP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-CELL CANCER; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; BLADDER-CANCER; OVARIAN-CANCER; ANALGESIC USE; CARCINOMA; PELVIS; ACETAMINOPHEN; URETER; PHENACETIN;
Keywords:
cancer; paracetamol; risk; epidemiology; cohort study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Friis, S Danish Canc Soc, Inst Canc Epidemiol, Strandboulevarden 49, DK-2100 Copenhagen, Denmark Danish Canc Soc Strandboulevarden 49 Copenhagen Denmark DK-2100
Citazione:
S. Friis et al., "Cancer risk in persons receiving prescriptions for paracetamol: A Danish cohort study", INT J CANC, 97(1), 2002, pp. 96-101

Abstract

The use of paracetamol has been associated with increased risks for urinary tract cancers and decreased risk for ovarian cancer, although results have been inconsistent. We conducted a population-based cohort study using data from the Prescription Database of North Jutland County and the Danish Cancer Registry. Cancer incidence among 39,946 individuals receiving prescriptions for paracetamol was compared with expected incidence based on the North Jutland population who did not receive paracetamol prescriptions, during a 9-year follow-up period. Standardized incidence ratios (SIRs) with corresponding 95% confidence intervals (95% Cis) were calculated for cancers overall and at selected sites. Overall, 2,173 cancers were observed with 1,973 expected, yielding a SIR of 1.10 (95% Cl, 1.06-1.15). Significantly elevated SIRs were found for cancers of the esophagus (1.9; 95% Cl, 1.3-2.8) and lung (1.6; 95% Cl, 1.4-1.7). Nonsignificantly increased SIRs were observed for cancers of the liver (1.5; 95% Cl, 0.96-2.2), renal parenchyma (1.3; 95%Cl, 0.9-1.7) and renal pelvis/ureter (1.6; 95% Cl, 0.96-2.6), whereas the SIR for cancer of the urinary bladder was close to unity (1. 1; 95% Cl, 0.9-1.4). For ovarian cancer, the SIR was close to expectation (0.9; 95% Cl, 0.6-1.2) with no evidence of trends with duration of follow-up or number of prescriptions. A similar risk pattern was observed after exclusion of person-time experience following prescription for aspirin or other nonsteroidal antiinflammatory drugs in the study cohort and reference population. Our results do not support a major role for paracetamol in the development of cancers of the urinary tract, and we found little evidence of a protective effect of paracetamol against ovarian cancer. The elevated risks for cancers of the esophagus, lung and liver are most likely a result of confounding variables, but may warrant further investigation. (C) 2002 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 13:40:19