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Titolo:
Epidemiology of reproductive and hormonal factors in thyroid cancer: Evidence from a case-control study in the Middle East
Autore:
Memon, A; Darif, M; Al-Saleh, K; Suresh, A;
Indirizzi:
Kuwait Univ, Fac Med, Dept Community Med & Behav Sci, Safat 13110, Kuwait Kuwait Univ Safat Kuwait 13110 nity Med & Behav Sci, Safat 13110, Kuwait Kuwait Canc Control, Kuwait, Kuwait Kuwait Canc Control Kuwait KuwaitKuwait Canc Control, Kuwait, Kuwait Parexel Int, San Diego, CA USA Parexel Int San Diego CA USAParexel Int, San Diego, CA USA
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 1, volume: 97, anno: 2002,
pagine: 82 - 89
SICI:
0020-7136(20020101)97:1<82:EORAHF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POOLED ANALYSIS; RISK-FACTORS; WOMEN; PREVALENCE; PREGNANCY; SMOKING; SERUM; THYROTROPIN; ESTROGEN; HISTORY;
Keywords:
reproductive factors; hormonal factors; thyroid cancer; etiology; case-control Study; women; Kuwait;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Memon, A Kuwait Univ, Fac Med, Dept Community Med & Behav Sci, POB 24923, Safat 13110, Kuwait Kuwait Univ POB 24923 Safat Kuwait 13110 23, Safat 13110, Kuwait
Citazione:
A. Memon et al., "Epidemiology of reproductive and hormonal factors in thyroid cancer: Evidence from a case-control study in the Middle East", INT J CANC, 97(1), 2002, pp. 82-89

Abstract

Thyroid cancer is the second most common neoplasm among women in Kuwait and several other countries in the Middle East. Most of these countries also have relatively high birth and total fertility rates. To examine potential relationships between reproductive and hormonal factors and thyroid cancer,we conducted a population-based case-control interview study among 238 women diagnosed with thyroid cancer and a similar number of individually matched controls in Kuwait. Among the demographic variables, women with 12+ years of education had a significantly reduced risk of thyroid cancer (OR = 0.4; 95% CI: 0.2-0.8; p-trend <0.05). The average age at diagnosis ( SD) of thyroid cancer was 34.7 +/- 11 years. Events such as age at menarche, pregnancy, menopausal status and age at menopause were not associated with thyroidcancer. There was an association with age at last pregnancy and parity. Women who had their last pregnancy at ages greater than or equal to 30 years were at a significantly increased risk (OR = 2.1; 95% CI: 1.2-3.8); there was also a significant trend in risk with increasing age at last pregnancy. There was a modest increase in risk among women who had borne greater than or equal to5 children (OR = 1.5; 95% CI: 0.9-2.5). A joint analysis of these factors showed that childbearing during the latter half of reproductive life had a substantial effect on the incidence of thyroid cancer; for any given level of parity, there was about a 2-fold increased risk if the age at last pregnancy was greater than or equal to 30 years. A substantial recent-birth effect, in relation to subsequent diagnosis of thyroid cancer, was observed during the second and third year after a birth (OR = 2.0; 95% CI: 1.0-4.1). In contrast, spontaneous abortion seemed to have a protective effect. There was a significant decrease in risk among women who had a miscarriage as outcome of first pregnancy (OR = 0.1; 95% CI: 0.03-0.4) and those whohad experienced greater than or equal to3 miscarriages (OR = 0.3; 95% CI: 0.1-0.8; p-trend <0.05). Overall, any female hormone use was not associatedwith thyroid cancer risk. New association is suggested for a history of post-partum thyroiditis (OR = 10.2; 95% CI: 2.3-44.8). These data support thehypothesis that reproductive factors and patterns may influence, or contribute to, the risk of thyroid cancer among women. (C) 2002 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:50:06