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Titolo:
A central role for IL-2 in fate determination of mature T cells - I: role in determining the T(h)1/T(h)2 profile in primary T cell cultures
Autore:
Raju, K; Rabinovich, BA; Radvanyi, LG; Spaner, D; Miller, RG;
Indirizzi:
Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada Univ Toronto Toronto ON Canada M5G 2M9 ophys, Toronto, ON M5G 2M9, Canada Univ Toronto, Dept Immunol, Toronto, ON M5G 2M9, Canada Univ Toronto Toronto ON Canada M5G 2M9 munol, Toronto, ON M5G 2M9, Canada Ontario Canc Inst, Toronto, ON M5G 2M9, Canada Ontario Canc Inst Toronto ON Canada M5G 2M9 , Toronto, ON M5G 2M9, Canada
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 12, volume: 13, anno: 2001,
pagine: 1453 - 1459
SICI:
0953-8178(200112)13:12<1453:ACRFII>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA PRODUCTION; LEISHMANIA-MAJOR; MONOCLONAL-ANTIBODY; RHEUMATOID-ARTHRITIS; AUTOIMMUNE-DISEASE; IFN-GAMMA; MICE; INTERLEUKIN-2; ACTIVATION; RECEPTOR;
Keywords:
autoimmunity; IFN-gamma; IL-2; IL-4; IL-5; IL-10; T(h)1; T(h)2; tumor necrosis factor-gamma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, RG Univ Toronto, Dept Med Biophys, 610 Univ Ave, Toronto, ON M5G 2M9, Canada Univ Toronto 610 Univ Ave Toronto ON Canada M5G 2M9 2M9, Canada
Citazione:
K. Raju et al., "A central role for IL-2 in fate determination of mature T cells - I: role in determining the T(h)1/T(h)2 profile in primary T cell cultures", INT IMMUNOL, 13(12), 2001, pp. 1453-1459

Abstract

IL-2 signaling appears to play a significant role in enabling the synthesis of T(h)2 cytokines in an in vitrosystem for studying primary T cell responses. When T cells from C57BL/6J or BALB/c strains of mice were activated in vitroand re-stimulated through their TCR complex 48 h later, CD4(+) T cells producing the T(h)2 cytokines IL-4 and IL-10 were found only when IL-2 was present. IL-2 also enhanced IFN-gamma synthesis in C57BL/6J cells but not in BALB/c cells. By up-regulating production of anti-inflammatory T(h)2 cytokines during a primary response, IL-2 may play a critical role in limiting T(h)1-mediated responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:50:38