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Titolo:
Scleroderma and occupational exposure to hand-transmitted vibration
Autore:
Bovenzi, M; Barbone, F; Pisa, FE; Betta, A; Romeo, L;
Indirizzi:
Univ Trieste, Trieste Gen Hosp, Dept Publ Hlth Sci, Clin Unit Occupat Med,I-34129 Trieste, Italy Univ Trieste Trieste Italy I-34129 it Occupat Med,I-34129 Trieste, Italy Univ Udine, DPMSC, Chair Hyg & Epidemiol, Udine, Italy Univ Udine Udine Italy dine, DPMSC, Chair Hyg & Epidemiol, Udine, Italy Autonomous Province Trento, NHS, Occupat Hlth Unit, Trento, Italy Autonomous Province Trento Trento Italy ccupat Hlth Unit, Trento, Italy Univ Verona, Inst Occupat Med, Verona, Italy Univ Verona Verona ItalyUniv Verona, Inst Occupat Med, Verona, Italy
Titolo Testata:
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
fascicolo: 8, volume: 74, anno: 2001,
pagine: 579 - 582
SICI:
0340-0131(200110)74:8<579:SAOETH>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC-SCLEROSIS; RAYNAUD PHENOMENON; SCLERODACTYLIA; SOLVENT;
Keywords:
case-control study; occupation; scleroderma; silica; hand-transmitted vibration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Bovenzi, M Univ Trieste, Trieste Gen Hosp, Dept Publ Hlth Sci, Clin Unit Occupat Med,Via Pieta 19, I-34129 Trieste, Italy Univ Trieste Via Pieta 19 Trieste Italy I-34129 Trieste, Italy
Citazione:
M. Bovenzi et al., "Scleroderma and occupational exposure to hand-transmitted vibration", INT A OCCUP, 74(8), 2001, pp. 579-582

Abstract

Objectives: To determine whether occupational exposure to hand-transmittedvibration is a risk factor for scleroderma (systemic sclerosis, SSc), two case-control studies were conducted in the provinces of Trento and Verona, northeastern Italy. Methods: In the Trento study, 21 patients with a diagnosis of either systemic or localised scleroderma were recruited from those admitted to all hospitals of the province from I January 1976 to 31 December1991. For each case, two age- and gender-matched controls were selected. In the Verona study, cases included 55 patients diagnosed with SSc and clinically followed at the rheumatology clinic of the local university hospital between I January 1997 and 30 June 1999. The controls included 171 subjectsfrequency-matched by gender and age group. In both studies, all subjects were interviewed by structured questionnaire containing items on personal characteristics, smoking and drinking habits, use of medicines, occupational history and complete medical history. Women were also investigated about silicone implants and cosmetic surgery. Jobs and job tasks involving the use of vibratory tools, with or without concomitant exposure to silica dust in mining and non-mining occupations, were carefully investigated. A minimum criterion of 6 months was required for exposure duration. Results: In the Trento Study, men with scleroderma were more likely than controls to have hadexposure to hand-transmitted vibration (odds ratio (OR) 1.5, 95% confidence interval (95% CI) 0.1-74.1) or silica dust (OR 5.2, 95% CI 0.5-74.1), butthe association was not significant. The scleroderma patients were miners or stone workers who had operated jackhammers and rock drills. In the Verona study, a greater, although not statistically significant, odds of SSc wasobserved in men exposed to hand-transmitted vibration (OR 2.4, 95% CI 0.4-14.0) and in women exposed to silica (OR 2.4, 95% CI 0.4-15.5). The SSc patients with vibration exposure were machinery operators or metal workers whohad used grinders and impact wrenches. Conclusions: Our case-control studies did not show a significant association between scleroderma and hand-transmitted vibration, with or without concomitant exposure to silica dust. Owing to the rarity of the disease and the small number of cases in the present studies, a genetic susceptibility to connective tissue disorders in SSc patients with occupational exposure to hand-transmitted vibration and/or silica cannot be ruled out.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 11:59:42