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Titolo:
Rapid secretion of interleukin-1 beta by microvesicle shedding
Autore:
MacKenzie, A; Wilson, HL; Kiss-Toth, E; Dower, SK; North, RA; Surprenant, A;
Indirizzi:
Univ Sheffield, Inst Mol Physiol, Sheffield S10 2TN, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2TN S Yorkshire, England Univ Sheffield, Sect Funct Genom, Sheffield S10 2TN, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2TN S Yorkshire, England
Titolo Testata:
IMMUNITY
fascicolo: 5, volume: 15, anno: 2001,
pagine: 825 - 835
SICI:
1074-7613(200111)15:5<825:RSOIBB>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-ASSOCIATED KINASE; IL-1-BETA RELEASE; DENDRITIC CELLS; PLASMA-MEMBRANE; HUMAN MONOCYTES; ANNEXIN-V; T-CELLS; ATP; DEATH; P2X(7);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Surprenant, A Univ Sheffield, Inst Mol Physiol, Sheffield S10 2TN, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2TN ngland
Citazione:
A. MacKenzie et al., "Rapid secretion of interleukin-1 beta by microvesicle shedding", IMMUNITY, 15(5), 2001, pp. 825-835

Abstract

The proinflammatory cytokine interleukin-1 beta (IL-1 beta) is a secreted protein that lacks a signal peptide and does not follow currently known pathways of secretion. Its efficient release from activated immune cells requires a secondary stimulus such as extracellular ATP acting on P2X(7) receptors. We show that human THP-1 monocytes shed microvesicles from their plasmamembrane within 2-5 s of activation of P2X(7) receptors. Two minutes aftersuch stimulation, the released microvesicles contained bioactive IL-1 beta, which only later appeared in the vesicle-free supernatant. We conclude that microvesicle shedding is a major secretory pathway for rapid IL-1 beta release from activated monocytes and may represent a more general mechanism for secretion of similar leaderless secretory proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 06:46:50