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Titolo:
The IL-7 receptor controls the accessibility of the TCR gamma locus by Stat5 and histone acetylation
Autore:
Ye, SK; Agata, Y; Lee, HC; Kurooka, H; Kitamura, T; Shimizu, A; Honjo, T; Ikuta, K;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Med Chem, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Med, Dept Med Chem, Kyoto 6068501, Japan Kyoto Univ, Ctr Mol Biol & Genet, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 tr Mol Biol & Genet, Kyoto 6068507, Japan Univ Tokyo, Inst Med Sci, Dept Hematopoiet Factors, Tokyo 1080071, Japan Univ Tokyo Tokyo Japan 1080071 Hematopoiet Factors, Tokyo 1080071, Japan
Titolo Testata:
IMMUNITY
fascicolo: 5, volume: 15, anno: 2001,
pagine: 813 - 823
SICI:
1074-7613(200111)15:5<813:TIRCTA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL DEVELOPMENT; INTERLEUKIN-7 RECEPTOR; V(D)J RECOMBINATION; GENE REARRANGEMENT; ALPHA; TRANSCRIPTION; ENHANCER; PROTEIN; REGION; P300;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Ikuta, K Kyoto Univ, Grad Sch Med, Dept Med Chem, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 t Med Chem, Kyoto 6068501, Japan
Citazione:
S.K. Ye et al., "The IL-7 receptor controls the accessibility of the TCR gamma locus by Stat5 and histone acetylation", IMMUNITY, 15(5), 2001, pp. 813-823

Abstract

The IL-7 receptor (IL-7R) plays critical roles in expansion and V(D)J recombination during lymphocyte development. Here we demonstrate that cytokine stimulation rapidly recruits Stat5 and transcriptional coactivators to the Jy germline promoter and induces histone acetylation, germline transcription, and accessibility in Ba/F3 cells. We also show that histone acetylation of the TCR gamma locus is significantly reduced in IL-7R-deficient thymocytes and that the introduction of active Stat5 restores the histone acetylation and accessibility of the locus. Furthermore, treatment with histone deacetylase inhibitor recovers the histone acetylation and accessibility in IL-7R-deficient thymocytes. Therefore, these results suggest that Stat5 may recruit the transcriptional coactivators to the Jy germline promoter and control the accessibility of the TCR gamma locus by histone acetylation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:37:34