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Titolo:
Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFN gamma-mediated B cell depletion
Autore:
Arens, R; Tesselaar, K; Baars, PA; van Schijndel, GMW; Hendriks, J; Pals, ST; Krimpenfort, P; Borst, J; van Oers, MHJ; van Lier, RAW;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Immunobiol, CLB,Sanquin Blood Supply Fdn, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam NetherlandsNL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Immunobiol, Expt & Clin Immunol Lab, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Hematol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Expt Immunol Lab, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Netherlands Canc Inst, Div Cellular Biochem, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands
Titolo Testata:
IMMUNITY
fascicolo: 5, volume: 15, anno: 2001,
pagine: 801 - 812
SICI:
1074-7613(200111)15:5<801:CCIIEO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NATURAL-KILLER-CELLS; FAMILY MEMBER CD27; N-TERMINAL KINASE; RECEPTOR FAMILY; COSTIMULATORY MOLECULES; ANTITUMOR IMMUNITY; TRANSGENIC MICE; CO-STIMULATION; DENDRITIC CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: van Lier, RAW Univ Amsterdam, Acad Med Ctr, Dept Immunobiol, CLB,Sanquin Blood Supply Fdn, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 9 Amsterdam Netherlands NL-1105 AZ
Citazione:
R. Arens et al., "Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFN gamma-mediated B cell depletion", IMMUNITY, 15(5), 2001, pp. 801-812

Abstract

The interaction between the TNF receptor family member CD27 and its ligandCD70 provides a costimulatory signal for T cell expansion. Normally, tightly regulated expression of CD70 ensures the transient availability of this costimulatory signal. Mice expressing constitutive CD70 on B cells had higher peripheral T cell numbers that showed increased differentiation toward effector-type T cells. B cell numbers in CD70 transgenic (TG) mice progressively decreased in primary and secondary lymphoid organs. This B cell depletion was caused by CD27-induced production of IFN gamma in T cells. We conclude that apart from its role in controlling the size of the activated T cell pool, CD27 ligation contributes to immunity by facilitating effector T cell differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:12:01