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Titolo:
Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein
Autore:
Boackle, SA; Holers, VM; Chen, XJ; Szakonyi, G; Karp, DR; Wakeland, EK; Morel, L;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80262 USA Univ ColoradoDenver CO USA 80262 Sci Ctr, Dept Med, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Dept Immunol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Ctr, Dept Immunol, Denver, CO 80262 USA Univ Texas, SW Med Ctr, Harold C Simmons Arthritis Res Ctr, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 ns Arthritis Res Ctr, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 r, Dept Internal Med, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Med Ctr, Ctr Immunol, Dallas, TX 75235 USA Univ Florida, Dept Med, Gainesville, FL 32608 USA Univ Florida Gainesville FL USA 32608 Dept Med, Gainesville, FL 32608 USA Univ Florida, Dept Pathol, Gainesville, FL 32608 USA Univ Florida Gainesville FL USA 32608 t Pathol, Gainesville, FL 32608 USA
Titolo Testata:
IMMUNITY
fascicolo: 5, volume: 15, anno: 2001,
pagine: 775 - 785
SICI:
1074-7613(200111)15:5<775:CACGIT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE COMPLEMENT RECEPTOR-1; B-CELL HYPERACTIVITY; T-DEPENDENT ANTIGEN; ERYTHEMATOSUS SLE; LIGAND-BINDING; LYMPHOCYTES-B; TYPE-1 CR-1; EXPRESSION; CD21; DISSECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Boackle, SA Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 t Med, Denver, CO 80262 USA
Citazione:
S.A. Boackle et al., "Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein", IMMUNITY, 15(5), 2001, pp. 775-785

Abstract

The major murine systemic lupus erythematosus (SLE) susceptibility locus, Sle1, corresponds to three loci independently affecting loss of tolerance to chromatin in the NZM2410 mouse. The congenic interval corresponding to Sle1c contains Cr2, which encodes complement receptors 1 and 2 (CR1/CR2, CD35/CD21). NZM2410/NZW Cr2 exhibits a single nucleotide polymorphism that introduces a novel glycosylation site, resulting in higher molecular weight proteins. This polymorphism, located in the Cad binding domain, reduces ligandbinding and receptor-mediated cell signaling. Molecular modeling based on the recently solved CR2 structure in complex with Cad reveals that this glycosylation interferes with receptor dimerization. These data demonstrate a functionally significant phenotype for the NZM2410 Cr2 allele and strongly support its role as a lupus susceptibility gene.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:29:05