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Titolo:
The expression of E-cadherin and catenins in sporadic colorectal carcinoma
Autore:
El-Bahrawy, MA; Poulsom, R; Jeffery, R; Talbot, A; Alison, MR;
Indirizzi:
Imperial Coll Sch Med, Hammersmith Hosp, Dept Histopathol, London W12 ONN,England Imperial Coll Sch Med London England W12 ONN hol, London W12 ONN,England Imperial Canc Res Fund, Lincolns Inn Fields, London WC2A 3PX, England Imperial Canc Res Fund London England WC2A 3PX London WC2A 3PX, England St Marks Hosp, Imperial Canc Res Fund, Colorectal Unit, London EC1V 2PS, England St Marks Hosp London England EC1V 2PS tal Unit, London EC1V 2PS, England
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 11, volume: 32, anno: 2001,
pagine: 1216 - 1224
SICI:
0046-8177(200111)32:11<1216:TEOEAC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL-ADHESION; HUMAN GASTRIC-CANCER; MOLECULE E-CADHERIN; L-CAM EXPRESSION; BETA-CATENIN; ALPHA-CATENIN; IMMUNOHISTOCHEMICAL EVALUATION; TYROSINE PHOSPHORYLATION; COLON-CARCINOMA; PROSTATE-CANCER;
Keywords:
E-cadherin; catenin; colorectal carcinomas;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Alison, MR Imperial Coll Sch Med, Hammersmith Hosp, Dept Histopathol, London W12 ONN,England Imperial Coll Sch Med London England W12 ONN W12 ONN,England
Citazione:
M.A. El-Bahrawy et al., "The expression of E-cadherin and catenins in sporadic colorectal carcinoma", HUMAN PATH, 32(11), 2001, pp. 1216-1224

Abstract

The E-cadherin/catenin complex plays a major role in epithelial cell-cell adhesion. Immunohistochemical studies have highlighted perturbation in the expression and distribution of E-cadherin and catenins in sporadic colorectal neoplasms. In this study, we compared the expression of E-cadherin and catenins (alpha-, beta-, and gamma -catenin) in 30 sporadic colorectal carcinomas with that in the adjacent nonneoplastic mucosa and assessed whether any perturbation in the level of expression occurred at the messenger RNA (mRNA) or protein level. We also compared the expression of E-cadherin and catenins in 13 lymph node deposits and the primary tumors. Immunohistochemistry was used to study the level of expression and cellular distribution of E-cadherin and catenins. Levels of mRNA were studied by in situ hybridization. E-cadherin and catenin immunoreactivity, was increased with cytoplasmic accumulation in more than 85% of the neoplasms. There were marked increasesin the levels of mRNA in the carcinomas compared with the nonneoplastic mucosa. Nuclear localization of beta -catenin was higher at the invasive margin of some tumors, but expression of E-cadherin and catenin transcripts in the lymph node deposits showed no consistent relationship to that in the primary tumors. Hum PATHOL 32:1216-1224, Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:39:47