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Titolo:
Mast cell distribution and activation in chronic pancreatitis
Autore:
Esposito, I; Friess, H; Kappeler, A; Shrikhande, S; Kleeff, J; Ramesh, H; Zimmermann, A; Buchler, MW;
Indirizzi:
Univ Bern, Inselspital, Dept Visceral & Transplantat Surg, CH-3010 Bern, Switzerland Univ Bern Bern Switzerland CH-3010 antat Surg, CH-3010 Bern, Switzerland Univ Bern, Inselspital, Inst Pathol, CH-3010 Bern, Switzerland Univ Bern Bern Switzerland CH-3010 nst Pathol, CH-3010 Bern, Switzerland PVS Mem Hosp, Cochin, Kerala, India PVS Mem Hosp Cochin Kerala IndiaPVS Mem Hosp, Cochin, Kerala, India
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 11, volume: 32, anno: 2001,
pagine: 1174 - 1183
SICI:
0046-8177(200111)32:11<1174:MCDAAI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; C-KIT RECEPTOR; INFLAMMATORY-BOWEL-DISEASE; NECROSIS-FACTOR-ALPHA; MEDIATOR RELEASE; DIFFERENTIAL EXPRESSION; GENE-EXPRESSION; SUBSTANCE-P; LIGAND; TRYPTASE;
Keywords:
mast cells; chronic pancreatitis; stem cell factor; IgE; tryptase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Friess, H Univ Heidelberg, Dept Gen Surg, Neuenheimer Feld 110, D-69120 Heidelberg, Germany Univ Heidelberg Neuenheimer Feld 110 Heidelberg Germany D-69120
Citazione:
I. Esposito et al., "Mast cell distribution and activation in chronic pancreatitis", HUMAN PATH, 32(11), 2001, pp. 1174-1183

Abstract

Chronic pancreatitis (CP) is characterized by mononuclear inflammatory cell infiltration and replacement of the destroyed parenchyma by fibrous tissue. Recently, mast cells have been implicated in chronic inflammatory processes with fibrous tissue deposition. Therefore, the number and distribution of mast cells and their state of activation were evaluated in 12 normal specimens and in 46 specimens of CP with different causes (alcoholic, tropical, and idiopathic). Furthermore, the presence of stem cell factor (SCF), themain mast cell growth factor, and of its receptor, c-kit, was also assessed. In CP tissues, mast cells were localized both in the fibrotic areas and in the residual acinar parenchyma. The total number of mast cells was significantly higher in CP than in the normal pancreas (P <.0001) and correlatedpositively with the extent of fibrosis and the intensity of inflammation. Immunoglobulin E (IgE)-dependent mast cell activation was higher in CP thanin the normal pancreas. No differences in mast cell number or IgE positivity were found among the 3 causes of CP. SCF- and c-kit-immunoreactive mast cells were mostly localized in fibrous tissue and around regenerating ducts, which were also positive for c-kit but were negative for SCF. These results suggest that mast cells, activated by an IgE-dependent mechanism and/or by an SCF-c-kit autocrine loop, are a relevant component of the inflammatory infiltrate in CP, independent of the underlying cause. Their localizationnear degenerating acini and regenerating ducts might indicate that they play a crucial role in tissue destruction and remodeling in CP. Hum PATHOL 32:1174-1183. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 00:44:08