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Titolo:
A probabilistic human health risk assessment for environmental exposure todibutylphthalate
Autore:
Vermeire, T; Jager, T; Janssen, G; Bos, P; Pieters, M;
Indirizzi:
Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands Natl Inst Publ Hlth & Environm Bilthoven Netherlands NL-3720 BA herlands TNO Nutr & Food Res, NL-3700 AJ Zeist, Netherlands TNO Nutr & Food Res Zeist Netherlands NL-3700 AJ 0 AJ Zeist, Netherlands
Titolo Testata:
HUMAN AND ECOLOGICAL RISK ASSESSMENT
fascicolo: 6, volume: 7, anno: 2001,
pagine: 1663 - 1679
SICI:
1080-7039(200111)7:6<1663:APHHRA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIC-CHEMICALS; BIOCONCENTRATION; UNCERTAINTY; VARIABILITY; VEGETATION; FRAMEWORK; MODEL; MILK;
Keywords:
uncertainty; variability; assessment factors; CAS Registry No. 84-74-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Vermeire, T Natl Inst Publ Hlth & Environm, POB 1, NL-3720 BA Bilthoven, Netherlands Natl Inst Publ Hlth & Environm POB 1 Bilthoven Netherlands NL-3720 BA
Citazione:
T. Vermeire et al., "A probabilistic human health risk assessment for environmental exposure todibutylphthalate", HUM ECOL R, 7(6), 2001, pp. 1663-1679

Abstract

In the European Union, Directive 92/32/EC and EC Council Regulation (EC) 793/93 require the risk assessment of industrial chemicals. In this framework, it is agreed to characterise the level of "risk" by means of the deterministic quotient of exposure and effects parameters. Decision makers requirethat the uncertainty in the risk assessment be accounted for as explicitlyas possible. Therefore, this paper intends to show the advantages and possibilities of a probabilistic human health risk assessment of an industrial chemical, dibutylphthalate (DBP). The risk assessment is based on non-cancer endpoints assumed to have a threshold for toxicity. This example risk assessment shows that a probabilistic risk assessment in the EU framework covering both die exposure and the effects assessment is feasible with currently available techniques. It shows the possibility of comparing the various uncertainties involved in a typical risk assessment, including the uncertainty in the exposure estimate, the uncertainty in the effect parameter, and the uncertainty in assessment factors used in the extrapolation from experimental animals to sensitive human beings. The analysis done did not confirm the reasonable worst-case character of the deterministic EU-assessment of DBP. Sensitivity analysis revealed the extrapolation procedure in the human effects assessment to be the main source of uncertainty. Since the probabilistic approach allows determination of the range of possible outcomes and their likelihood, it better informs both risk assessors and risk managers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:41:32