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Titolo:
Notch receptor expression in adult human liver: A possible role in bile duct formation and hepatic neovascularization
Autore:
Nijjar, SS; Crosby, HA; Wallace, L; Hubscher, SG; Strain, AJ;
Indirizzi:
Queen Elizabeth Hosp, Liver Res Labs, Inst Clin Res, Birmingham B15 2TH, WMidlands, England Queen Elizabeth Hosp Birmingham W Midlands England B15 2TH lands, England Univ Birmingham, Sch Biosci, Birmingham, W Midlands, England Univ Birmingham Birmingham W Midlands England ngham, W Midlands, England Univ Birmingham, Dept Pathol, Birmingham, W Midlands, England Univ Birmingham Birmingham W Midlands England ngham, W Midlands, England
Titolo Testata:
HEPATOLOGY
fascicolo: 6, volume: 34, anno: 2001,
pagine: 1184 - 1192
SICI:
0270-9139(200112)34:6<1184:NREIAH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY BILIARY-CIRRHOSIS; GROWTH-FACTOR; SCLEROSING CHOLANGITIS; ALAGILLE-SYNDROME; PROGENITOR CELLS; EPITHELIAL-CELLS; DELTA-HOMOLOG; JAGGED1 GENE; MUTATIONS; LIGAND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Strain, AJ Queen Elizabeth Hosp, Liver Res Labs, Inst Clin Res, Clin Res Block, Birmingham B15 2TH, W Midlands, England Queen Elizabeth Hosp Clin ResBlock Birmingham W Midlands England B15 2TH
Citazione:
S.S. Nijjar et al., "Notch receptor expression in adult human liver: A possible role in bile duct formation and hepatic neovascularization", HEPATOLOGY, 34(6), 2001, pp. 1184-1192

Abstract

Notch signaling is an evolutionarily conserved mechanism, used to regulatecell fate decisions. Four Notch receptors have been identified in man (Notch-1 to -4). In this study, semiquantitative reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry were used to examine the expression pattern of Notch receptor genes in whole adult human liver andisolated liver cell preparations. All 4 receptors were expressed in the adult liver. with no significant differences in the levels of Notch-1, -2, and -4 messenger RNA (mRNA) between normal and diseased liver. However, Notch-3 expression appeared to be increased in diseased tissue. The distributionof Notch-1 and -4 in normal tissue was similar, with Notch-l also detectable at low levels in the sinusoidal endothelium. Notch-2 expression was morewidely distributed, and detectable in hepatocytes, medium-sized bile ducts, and the sinusoidal endothelium. Notch-3 expression was seen on hepatocytes with weaker expression detectable in portal veins, hepatic arteries, and the sinusoids. In normal liver tissue Notch-1, -2, and -3 were found to be coexpressed on bile duct epithelium; however, with the exception of Notch-3in primary sclerosing cholangitis (PSC) livers, expression was absent on proliferating ductules in all disease states examined. Interestingly, the expression of Notch-2 and -3 was associated with numerous small vessels within the portal tract septa of diseased tissue. The absence of Notch receptor expression on proliferating bile ductules and its presence on neovessels suggests that Notch signaling may be important for normal bile duct formationand the aberrant neovascularization seen in diseased liver tissue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 04:43:03