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Titolo:
Factor V Leiden mutation and the risk of venous thromboembolism in pregnant women
Autore:
Tormene, D; Simioni, P; Prandoni, P; Luni, S; Zerbinati, P; Sartor, D; Franz, F; Girolami, A;
Indirizzi:
Univ Padua, Sch Med, Dept Med & Surg Sci, Chair Internal Med 2, I-35128 Padua, Italy Univ Padua Padua Italy I-35128 hair Internal Med 2, I-35128 Padua, Italy
Titolo Testata:
HAEMATOLOGICA
fascicolo: 12, volume: 86, anno: 2001,
pagine: 1305 - 1309
SICI:
0390-6078(200112)86:12<1305:FVLMAT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEEP-VEIN THROMBOSIS; ORAL-CONTRACEPTIVE USE; LUPUS ANTICOAGULANT; PROTHROMBIN GENE; POPULATION; THROMBOPHILIA; PUERPERIUM; PREVALENCE; FREQUENCY; HISTORY;
Keywords:
factor V Leiden; homozygous defect; pregnancy; venous thromboembolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Simioni, P Univ Padua, Sch Med, Dept Med & Surg Sci, Chair Internal Med 2,Via Osped Civile 105, I-35128 Padua, Italy Univ Padua Via Osped Civile 105Padua Italy I-35128 dua, Italy
Citazione:
D. Tormene et al., "Factor V Leiden mutation and the risk of venous thromboembolism in pregnant women", HAEMATOLOG, 86(12), 2001, pp. 1305-1309

Abstract

Background and Objectives. In this retrospective, single center, cohort study we assessed the risk of pregnancy-related venous thromboembolism (VTE) in women belonging to a large number of families identified because of a symptomatic proband with single identified factor V Leiden mutation. Design and Methods. Female family members who had experienced at least onefull-term pregnancy were enrolled in the study. Two hundred and seventy pregnancies occurred in 105 carriers and 215 pregnancies in 81 non-carriers of factor V Leiden mutation. Results. The frequency of VTE was 6.4% for heterozygous, 16.7% for homozygous, 20% for double heterozygous carriers of thrombophilic defects, and 1.2% for non-carriers. The majority of VTE events related to pregnancy occurred in the post-partum period. The relative risks of developing pregnancy-related VTE in women who were carriers of heterozygous and homozygous (or combined heterozygous) factor V Leiden mutation as compared to non-carriers were 5.3 (95% CI, 0.6 to 43.9) and 15.4 (95% CI, 1.4 to 164), respectively. Interpretation and Conclusions. Factor V Leiden mutation is a risk factor for pregnancy-related VTE, especially in its homozygous form and in combination with other thrombophilic abnormalities. Screening of families with this mutation might be useful for women of fertile age, as they may take advantage from thromboprophylaxis during pregnancy and the postpartum period. (C) 2001, Ferrata Storti Foundation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 03:53:13