Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparative genomic hybridization detects genetic alterations during earlystages of cervical cancer progression
Autore:
Umayahara, K; Numa, F; Suehiro, Y; Sakata, A; Nawata, S; Ogata, H; Suminami, Y; Sakamoto, M; Sasaki, K; Kato, H;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Obstet & Gynecol, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Kyoundo Hosp, Sasaki Inst, Dept Gynecol, Tokyo, Japan Kyoundo Hosp TokyoJapan Hosp, Sasaki Inst, Dept Gynecol, Tokyo, Japan Yamaguchi Univ, Sch Med, Dept Pathol, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 1, volume: 33, anno: 2002,
pagine: 98 - 102
SICI:
1045-2257(200201)33:1<98:CGHDGA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
UTERINE CERVIX; INTRAEPITHELIAL NEOPLASIA; NATURAL-HISTORY; IN-SITU; CARCINOMA; AMPLIFICATION; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Umayahara, K Yamaguchi Univ, Sch Med, Dept Obstet & Gynecol, 1-1-1 Minami Kogushi, Ube,Yamaguchi 7558505, Japan Yamaguchi Univ 1-1-1 Minami Kogushi Ube Yamaguchi Japan 7558505
Citazione:
K. Umayahara et al., "Comparative genomic hybridization detects genetic alterations during earlystages of cervical cancer progression", GENE CHROM, 33(1), 2002, pp. 98-102

Abstract

Invasive cervical carcinoma is thought to arise from cervical intraepithelial neoplasm (CIN). Genetic changes that occur during progression of CIN tocervical carcinoma are poorly understood, although they appear to be directly involved in this process. We used comparative genomic hybridization (CGH) with precise microdissection and degenerate oligonucleotide primed-polymerase chain reaction (DOP-PCR) to detect genetic alterations in normal epithelial, CIN, and invasive carcinoma tissues colocalized in tumors from 18 patients with squamous cell carcinoma of the uterine cervix. Gains on chromosome I and on 3q and losses on 2q, 3p, 4, 6p, 11q, and 17p were frequent alterations found in CIN and invasive carcinoma lesions. Interestingly, several of these genetic changes were observed in preinvasive carcinoma lesions. The frequency and average number of genetic alterations corresponded directly to the extent to which the cervical carcinoma had progressed. Frequent alterations were found in more than 90% of CIN III lesions. Gains on 3q andlosses on 11q were the most prevalent genetic alterations found in association with uterine cervix carcinogenesis. The common regions of alteration were 3q26.1-q28 and 11q23-qter. The majority of tumor samples showed variability in genetic alterations across lesion types within a single specimen. (C) 2002 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:02:20