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Titolo:
Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability
Autore:
Shimizu, Y; Ikeda, S; Fujimori, M; Kodama, S; Nakahara, M; Okajima, M; Asahara, T;
Indirizzi:
Hiroshima Univ, Fac Med, Dept Surg 2, Minami Ku, Hiroshima, Japan Hiroshima Univ Hiroshima Japan Dept Surg 2, Minami Ku, Hiroshima, Japan
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 1, volume: 33, anno: 2002,
pagine: 73 - 81
SICI:
1045-2257(200201)33:1<73:FAITWS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOMATOUS POLYPOSIS-COLI; APC TUMOR-SUPPRESSOR; BETA-CATENIN MUTATIONS; GERM-LINE MUTATIONS; SOMATIC MUTATIONS; GSK-3-BETA-DEPENDENT PHOSPHORYLATION; HEPATOCELLULAR CARCINOMAS; NEGATIVE REGULATOR; DIRECTLY INTERACTS; MISMATCH REPAIR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Ikeda, S Hiroshima Univ, Fac Med, Dept Surg 2, Minami Ku, 1-2-3 Kasumi, Hiroshima, Japan Hiroshima Univ 1-2-3 Kasumi Hiroshima Japan i, Hiroshima, Japan
Citazione:
Y. Shimizu et al., "Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability", GENE CHROM, 33(1), 2002, pp. 73-81

Abstract

It is generally accepted that both dysfunction of the Writ signaling pathway, including mutations in the adenomatous polyposis coli (APC) and beta -catenin genes, and genetic instability play important roles in colorectal carcinogenesis. However, alteration of the components in the Writ signaling pathway in colorectal cancer (CRC) with microsatellite instability (MSI) hasnot been elucidated. In order to assess the status of the Wnt signaling components in CRC with MSI, mutational analyses of the beta -catenin, APC, Axin 1, and T cell factor 4 (TCF4) genes:were performed. Three of 33 samples had mutations in exon 3 of the beta -catenin gene and two in the APC gene. Eight mutations in seven samples were detected by single-strand conformation polymorphism and subsequent direct sequence analysis of the entire codingregion of the Axin 1 gene. Furthermore, TCF4, which is one of the transcriptional factors in the Writ signaling pathway and has a mononucleotide repeat sequence (a nine-adenine repeat, (A)9) in its C-terminal region, was mutated in 13 of the 33 samples. Thus, alteration in the Wnt signaling pathwayis frequently observed in CRC with MSI, including hereditary nonpolyposis colorectal cancer, as well as in familial adenomatous polyposis and sporadic CRC without MSI. (C) 2002 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:23:01