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Titolo:
Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH
Autore:
Van Limbergen, H; Poppe, B; Michaux, L; Herens, C; Brown, J; Noens, L; Berneman, Z; De Bock, R; De Paepe, A; Speleman, F;
Indirizzi:
State Univ Ghent Hosp, Ctr Med Genet, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 Genet, B-9000 Ghent, Belgium UCL, Clin Univ St Luc, Ctr Human Genet, Brussels, Belgium UCL Brussels Belgium in Univ St Luc, Ctr Human Genet, Brussels, Belgium UCL, Clin Univ St Luc, Dept Hematol, Brussels, Belgium UCL Brussels Belgium Clin Univ St Luc, Dept Hematol, Brussels, Belgium Univ Liege, Dept Human Genet, Liege, Belgium Univ Liege Liege BelgiumUniv Liege, Dept Human Genet, Liege, Belgium Inst Mol Med, Mol Haematol Unit, MRC, Oxford, England Inst Mol Med Oxford England ed, Mol Haematol Unit, MRC, Oxford, England State Univ Ghent Hosp, Dept Haematol, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 ematol, B-9000 Ghent, Belgium Univ Antwerp Hosp, Dept Haematol, Edegem, Belgium Univ Antwerp Hosp Edegem Belgium p Hosp, Dept Haematol, Edegem, Belgium AZ Middelheim, Dept Haematol, Antwerp, Belgium AZ Middelheim Antwerp Belgium ddelheim, Dept Haematol, Antwerp, Belgium
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 1, volume: 33, anno: 2002,
pagine: 60 - 72
SICI:
1045-2257(200201)33:1<60:IOCSAR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; IN-SITU HYBRIDIZATION; MYELODYSPLASTIC SYNDROME; ABNORMALITIES; GENE; TRANSLOCATIONS; AMPLIFICATION; FUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Speleman, F State Univ Ghent Hosp, Ctr Med Genet, De Pintelaan 185, B-9000Ghent, Belgium State Univ Ghent Hosp De Pintelaan 185 Ghent Belgium B-9000 m
Citazione:
H. Van Limbergen et al., "Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH", GENE CHROM, 33(1), 2002, pp. 60-72

Abstract

Complex chromosomal aberrations (CCAs) can be detected in a substantial proportion of AML and MDS patients, de novo as well as secondary or therapy-related, and are associated with an adverse prognosis. Comprehensive analysis of the chromosomal rearrangements in these complex karyotypes has been hampered by the limitations of conventional cytogenetics. As a result, our knowledge concerning the cytogenetics of these malignancies is sparse. Here we describe a multiplex-FISH (M-FISH) study of CCAs in 36 patients with AML and MDS. IM-FISH generated a genome-wide analysis of chromosomal aberrations in CCAs, establishing several cytogenetic subgroups. -5/5q- was demonstrated in the majority of patients (86%). Other rearrangements (present with or without -5/5q-) included; deletion of 7q (47%), 3q rearrangements (19%), and MLL copy gain or amplification (17%). These genetic subgroups seem to display biological heterogeneity; MLL copy gain or amplification in association with 5q- was detected only in AML patients and was significantly associated with extremely short survival (median overall survival; 30 days, P = 0.0102). A partially cryptic t(4;5)(q31;q31), a balanced t(1;8)(p31;q22), and an unbalanced der(7)t(7;14)(q21;q13) were detected as possible new recurrent rearrangements in association with CCAs. Novel reciprocal translocations included t(5;11)(q33;p15)del(5)(q13q31) and t(3;6)(q26;q25). We conclude that AML and MDS with CCAs can be subdivided into molecular cytogenetic Subclasses, which could reflect different clinical behavior and prognosis, andthat three recurrent chromosomal aberrations are associated with karyotypecomplexity. (C) 2002 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:21:38