Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cytogenetic clues to breast carcinogenesis
Autore:
Teixeira, MR; Pandis, N; Heim, S;
Indirizzi:
Portuguese Oncol Inst, Dept Genet, P-4200072 Oporto, Portugal Portuguese Oncol Inst Oporto Portugal P-4200072 4200072 Oporto, Portugal St Savas Hosp, Dept Genet, Athens, Greece St Savas Hosp Athens GreeceSt Savas Hosp, Dept Genet, Athens, Greece Norwegian Radium Hosp, Dept Canc Genet, Oslo, Norway Norwegian Radium Hosp Oslo Norway m Hosp, Dept Canc Genet, Oslo, Norway
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 1, volume: 33, anno: 2002,
pagine: 1 - 16
SICI:
1045-2257(200201)33:1<1:CCTBC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; HOMOGENEOUSLY STAINING REGIONS; PRIMARY CHROMOSOME ABNORMALITY; LYMPH-NODE METASTASES; SHORT-TERM CULTURE; CARCINOMA IN-SITU; CLONAL ANALYSIS; SOLID TUMORS; INTRATUMOR HETEROGENEITY; GENETIC ALTERATIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Teixeira, MR Portuguese Oncol Inst, Dept Genet, Rua Dr Antonio Bernardino de Almeida, P-4200072 Oporto, Portugal Portuguese Oncol Inst Rua Dr AntonioBernardino de Almeida Oporto Portugal P-4200072
Citazione:
M.R. Teixeira et al., "Cytogenetic clues to breast carcinogenesis", GENE CHROM, 33(1), 2002, pp. 1-16

Abstract

The somatic mutation theory of cancer maintains that tumorigenesis is driven by genetic alterations, many of which are visible cytogenetically. We have examined breast cancer by chromosome banding analysis after short-term culturing of tumor cells and here review our findings in 322 karyotypically abnormal samples obtained since: 1992 from 256 patients. The screening capabilities of this technique enabled us to identify several cytogenetic subgroups of breast cancer, to study the intratumor heterogeneity of breast carcinomas, and to compare primary tumors with their metastases. Using chromosome abnormalities as clonality markers, we could determine on an individual basis when multiple,! ipsilateral or bilateral breast, tumors were independent de novo carcinomas and when they resulted from the spreading of a single malignant clone within one breast or from one breast to the other. The distribution of chromosomal breakpoints and genomic gains and losses is clearly nonrandom in breast cancer, something that can guide further investigations using molecular methods. Based on the total dataset, we propose a multipathway model of mammary carcinogenesis that takes into consideration the genetic heterogeneity revealed by the karyotypic findings and review the karyotypic-pathologic correlations and the possible clinical applications of the cytogenetic knowledge. (C) 2002 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:15:01