Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Genomic structure of the mouse PP4 gene: a developmentally regulated protein phosphatase
Autore:
Hu, MCT; Shui, JW; Mihindukulasuriya, KA; Tan, TH;
Indirizzi:
Baylor Coll Med, Dept Immunol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Dept Immunol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 l & Cellular Oncol, Houston, TX 77030 USA
Titolo Testata:
GENE
fascicolo: 1-2, volume: 278, anno: 2001,
pagine: 89 - 99
SICI:
0378-1119(20011031)278:1-2<89:GSOTMP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERINE/THREONINE PHOSPHATASES; CATALYTIC SUBUNIT; ALPHA4 PROTEIN; 2A; CENTROSOMES; NUCLEAR; IDENTIFICATION; ORGANIZATION; MICROTUBULES; HOMOLOG;
Keywords:
library screening; in situ hybridization; gene structure; gene expression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Tan, TH Baylor Coll Med, Dept Immunol, M929,1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med M929,1 Baylor Plaza Houston TX USA 77030 77030 USA
Citazione:
M.C.T. Hu et al., "Genomic structure of the mouse PP4 gene: a developmentally regulated protein phosphatase", GENE, 278(1-2), 2001, pp. 89-99

Abstract

Protein phosphatases play important roles in the control of various cellular processes. Here, we report the cloning and characterization of the murine cDNA and genomic DNA encoding the serine/threonine protein phosphatase 4 (PP4), also called PPX. While the nucleotide sequences of murine and human PP4 are distinct, their amino acid sequences are identical. We have analyzed the protein, cDNA and genomic PP4 sequences to provide insight into the structure, function and potential regulation of PP4. Genomic Southern blots demonstrated the conservation of PP4 across species. Using Northern blotting and in situ hybridization, we have examined the expression of PP4 in murine embryos and adult tissues. In adult tissues, PP4 was expressed at high levels in the testis, kidney, liver, and lung, and at lower levels in virtually all tissues. PP4 was differentially expressed in murine embryos at different developmental stages, suggesting that PP4 is a developmentally regulated protein phosphatase. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:21:31