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Titolo:
Cox-2 inhibitors - Are they nonsteroidal anti-inflammatory drugs with a better safety profile?
Autore:
Simon, LS;
Indirizzi:
Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med, Boston, MA02215 USA Harvard Univ Boston MA USA 02215 , Sch Med, Dept Med, Boston, MA02215 USA
Titolo Testata:
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
fascicolo: 4, volume: 30, anno: 2001,
pagine: 1011 -
SICI:
0889-8553(200112)30:4<1011:CI-ATN>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; ANTIINFLAMMATORY DRUGS; RHEUMATOID-ARTHRITIS; GASTROINTESTINAL TOXICITY; CYCLOOXYGENASE-2 INHIBITORS; COLORECTAL-CANCER; BLOOD-PRESSURE; DOUBLE-BLIND; OSTEOARTHRITIS; ROFECOXIB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Simon, LS Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med, 1 Deaconess Rd, Boston, MA 02215 USA Harvard Univ 1 Deaconess Rd Boston MA USA 02215 on, MA 02215 USA
Citazione:
L.S. Simon, "Cox-2 inhibitors - Are they nonsteroidal anti-inflammatory drugs with a better safety profile?", GASTRO CLIN, 30(4), 2001, pp. 1011

Abstract

In the treatment of arthritis, NSAIDs are some of the most commonly used drugs, although the prescription of such drugs has been questioned due to their inherent risks for gastrointestinal compromise, platelet effects, and the potential for renal toxicity with long-term use. With the availability of celecoxib and rofecoxib, 2 cyclooxygenase (COX-2) inhibitors (or COX-1 sparing agents) as new forms of NSAIDs, these issues have become magnified not only in the context of risk-to-benefit ratios but also in terms of pharmacoeconomics because they have been proven to be equally efficacious as the nonselective NSAIDs, with an improved safety profile particularly within the gastrointestinal tract, but at a significantly increased cost.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:47:28