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Titolo:
Role of cyclooxygenase inhibitors for the prevention of colorectal cancer
Autore:
Stack, E; DuBois, RN;
Indirizzi:
Vanderbilt Univ Med, Dept Cell Biol, Nashville, TN USA Vanderbilt Univ Med Nashville TN USA , Dept Cell Biol, Nashville, TN USA Vanderbilt Univ Med, Dept Med, Nashville, TN USA Vanderbilt Univ Med Nashville TN USA iv Med, Dept Med, Nashville, TN USA Dept Vet Affairs Med Ctr, Nashville, TN 37212 USA Dept Vet Affairs Med Ctr Nashville TN USA 37212 , Nashville, TN 37212 USA
Titolo Testata:
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
fascicolo: 4, volume: 30, anno: 2001,
pagine: 1001 -
SICI:
0889-8553(200112)30:4<1001:ROCIFT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; FAMILIAL ADENOMATOUS POLYPOSIS; RAT GASTROINTESTINAL-TRACT; MIN MOUSE ADENOMAS; COLON-CANCER; RHEUMATOID-ARTHRITIS; EPITHELIAL-CELLS; EXPRESSION; SULINDAC; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: DuBois, RN Vanderbilt Univ, Med Ctr, Dept Med GI, MCN C-2104,1161 21st AveS, Nashville, TN 37232 USA Vanderbilt Univ MCN C-2104,1161 21st Ave S Nashville TN USA 37232
Citazione:
E. Stack e R.N. DuBois, "Role of cyclooxygenase inhibitors for the prevention of colorectal cancer", GASTRO CLIN, 30(4), 2001, pp. 1001

Abstract

Prostaglandins (PGs) are mediators of physiologic functions and pathologicresponses. The diversity of PG activities is achieved by cell and tissue-specific generation of different stable PGs, multiple PG receptors linked todifferent intracellular signaling pathways, and PG production pathways involving enzymes that are induced to dramatically increase local PG production. This article will review mechanisms of PG production and action. Dissecting these biochemical and molecular pathways provides greater understandingof the clinical pharmacology of available inhibitors of PG production and may allow development of therapeutic agents that can be applied to specificclinical situations, while preserving PGs that play a role in normal physiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 10:25:50