Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Prostaglandin biology in inflammatory bowel disease
Autore:
Wallace, JL;
Indirizzi:
Univ Calgary, Dept Pharmacol & Therapeut, Mucosal Inflammat Res Grp, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 s Grp, Calgary, AB T2N 4N1, Canada
Titolo Testata:
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
fascicolo: 4, volume: 30, anno: 2001,
pagine: 971 -
SICI:
0889-8553(200112)30:4<971:PBIIBD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SELECTIVE CYCLO-OXYGENASE-2 INHIBITORS; HUMAN POLYMORPHONUCLEAR LEUKOCYTES; INTESTINAL EPITHELIAL-CELLS; ULCERATIVE-COLITIS; INTERLEUKIN-1 PRODUCTION; LEUCYL-PHENYLALANINE; MESENTERIC VENULES; MEDIATOR RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Wallace, JL Univ Calgary, Dept Pharmacol & Therapeut, Mucosal Inflammat Res Grp, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada Univ Calgary 3330 Hosp Dr NW Calgary AB Canada T2N 4N1 Canada
Citazione:
J.L. Wallace, "Prostaglandin biology in inflammatory bowel disease", GASTRO CLIN, 30(4), 2001, pp. 971

Abstract

Prostaglandins are critical mediators of virtually every aspect of mucosaldefense, explaining in part why nonsteroidal antiinflammatory drugs are able to cause injury throughout the gastrointestinal tract. When inflamed, gastrointestinal prostaglandin synthesis is derived largely from cyclooxygenase-2, in contrast to the normal situation. These prostaglandins play an important role in down-regulating inflammation and in promoting repair. Selective suppression of COX-2 has been shown, in experimental models, to cause an exacerbation of colitis and to increase the propensity for bacterial invasion of the intestinal mucosa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 15:35:21