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Titolo:
Resistance of human cerebrospinal fluid to in vitro oxidation is directly related to its amyloid-beta content
Autore:
Kontush, A; Donarski, N; Beisiegel, U;
Indirizzi:
Univ Hamburg, Hosp Eppendorf, Biochem Lab, Med Clin, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 Med Clin, D-20246 Hamburg, Germany
Titolo Testata:
FREE RADICAL RESEARCH
fascicolo: 5, volume: 35, anno: 2001,
pagine: 507 - 517
SICI:
1071-5762(2001)35:5<507:ROHCFT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; PERFORMANCE LIQUID-CHROMATOGRAPHY; ALZHEIMERS-DISEASE; A-BETA; PRECURSOR PROTEIN; HUMAN PLASMA; PHYSIOLOGICAL CONCENTRATIONS; DIFFERENT CONSTITUENTS; BLOOD-PLASMA; PEPTIDE;
Keywords:
amyloid-beta; cerebrospinal fluid; antioxidants; ascorbate; lipid peroxidation; Alzheimer's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Kontush, A Univ Hamburg, Hosp Eppendorf, Biochem Lab, Med Clin, Pav 39,Martinistr 52,D-20246 Hamburg, Germany Univ Hamburg Pav 39,Martinistr 52 Hamburg Germany D-20246 many
Citazione:
A. Kontush et al., "Resistance of human cerebrospinal fluid to in vitro oxidation is directly related to its amyloid-beta content", FREE RAD RE, 35(5), 2001, pp. 507-517

Abstract

Amyloid-beta (A beta) peptide, a major constituent of senile plaques and ahallmark of Alzheimer's disease (AD), is normally secreted by neurons and can be found in low concentrations in cerebrospinal fluid (CSF) and plasma where it is associated with lipoproteins. However, the physiological role of A beta secretion remains unknown. We measured the resistance to in vitro oxidation of CSF obtained from 20 control subjects and 30 patients with AD,and correlated it with CSF levels of antioxidants, lipids and A beta. We found that the oxidative resistance, expressed as a duration of the oxidation lag-phase, was directly related to CSF levels of A beta (1-40), A beta (1-42) and ascorbate and inversely to levels of fatty acids. These data suggest that, besides ascorbate, A beta is another major physiological antioxidant for CSF lipoproteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:26:37