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Titolo:
Quantitative grading of a human blastocyst: optimal inner cell mass size and shape
Autore:
Richter, KS; Harris, DC; Daneshmand, ST; Shapiro, BS;
Indirizzi:
Fertil Ctr Las Vegas, Las Vegas, NV 89117 USA Fertil Ctr Las Vegas Las Vegas NV USA 89117 egas, Las Vegas, NV 89117 USA Univ Nevada, Sch Med, Dept Obstet & Gynecol, Las Vegas, NV 89154 USA Univ Nevada Las Vegas NV USA 89154 tet & Gynecol, Las Vegas, NV 89154 USA
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 6, volume: 76, anno: 2001,
pagine: 1157 - 1167
SICI:
0015-0282(200112)76:6<1157:QGOAHB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO FERTILIZATION; INTRACYTOPLASMIC SPERM INJECTION; EMBRYO-TRANSFER; PREIMPLANTATION DEVELOPMENT; IMPLANTATION RATES; ELECTIVE TRANSFER; PREDICTIVE VALUE; PREGNANCY RATES; BOVINE EMBRYO; QUALITY;
Keywords:
in vitro fertilization; blastocyst transfer; blastocyst expansion; blastocyst size; trophectoderm cell number; inner cell mass size and shape; quantitative measurements; implantation rate; pregnancy rate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Shapiro, BS Fertil Ctr Las Vegas, 8851 W Sahara Ave,Suite 100, Las Vegas, NV 89117 USA Fertil Ctr Las Vegas 8851 W Sahara Ave,Suite 100 Las Vegas NV USA 89117
Citazione:
K.S. Richter et al., "Quantitative grading of a human blastocyst: optimal inner cell mass size and shape", FERT STERIL, 76(6), 2001, pp. 1157-1167

Abstract

Objective: To investigate the predictive value of quantitative measurements of blastocyst morphology on subsequent implantation rates after transfer. Design: Prospective observational study. Setting: Private assisted reproductive technology center. Patient(s): One hundred seventy-four IVF patients receiving transfers of expanded blastocyst-stage embryos on day 5 (n = 112) or day 6 (n = 62) afteroocyte retrieval. Intervention(s): None. Main Outcome Measure(s): Blastocyst diameter, number of trophectoderm cells, inner cell mass (ICM) size, ICM shape, and implantation and pregnancy rates. Result(s): Blastocyst diameter and trophectoderm cell numbers were unrelated to implantation rates. Day 5 expanded blastocysts with ICMs of >4,500 mum(2) implanted at a higher rate than did those with smaller ICMs (55% vs. 31%). Day 5 expanded blastocysts with slightly oval ICMs implanted at a higher rate (58%) compared with those with either rounder ICMs (7%) or more elongated ICMs (33%). Implantation rates were highest (71%) for embryos with both optimal ICM size and shape. Pregnancy rates were higher for day 5 transfers of optimally shaped ICMs compared with day 5 transfers of optimally sized ICMs. Conclusion(s): Quantitative measurements of the inner cell mass are highlyindicative of blastocyst implantation potential. Blastocysts with relatively large and/or slightly oval ICMs are more likely to implant than other blastocysts. (Fertil Steril (R) 2001;76:1157-67. (C) 2001 by American Societyfor Reproductive Medicine.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 04:06:37