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Titolo:
Contextual fear conditioning is disrupted by lesions of the subcortical, but not entorhinal, connections to the hippocampus
Autore:
Bannerman, DM; Yee, BK; Lemaire, M; Jarrard, L; Iversen, SD; Rawlins, JNP; Good, MA;
Indirizzi:
Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England Univ Oxford Oxford England OX1 3UD Expt Psychol, Oxford OX1 3UD, England Univ Hong Kong, Fac Med, Dept Anat, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Porsolt & Partners Pharmacol, F-92100 Boulogne, France Porsolt & Partners Pharmacol Boulogne France F-92100 00 Boulogne, France Washington & Lee Univ, Dept Psychol, Lexington, VA 24450 USA Washington & Lee Univ Lexington VA USA 24450 hol, Lexington, VA 24450 USA Univ Wales Coll Cardiff, Sch Psychol, Cardiff CF10 3YG, S Glam, Wales UnivWales Coll Cardiff Cardiff S Glam Wales CF10 3YG 3YG, S Glam, Wales
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 3, volume: 141, anno: 2001,
pagine: 304 - 311
SICI:
0014-4819(200112)141:3<304:CFCIDB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIRHINAL CORTEX; DORSAL HIPPOCAMPUS; BASOLATERAL AMYGDALA; ELECTROLYTIC LESIONS; RETROGRADE-AMNESIA; NUCLEUS-ACCUMBENS; RAT; PROJECTION; MEMORY; ORGANIZATION;
Keywords:
entorhinal cortex; hippocampus; fimbria fornix; contextual freezing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Bannerman, DM Univ Oxford, Dept Expt Psychol, S Parks Rd, Oxford OX1 3UD, England Univ Oxford S Parks Rd Oxford England OX1 3UD 3UD, England
Citazione:
D.M. Bannerman et al., "Contextual fear conditioning is disrupted by lesions of the subcortical, but not entorhinal, connections to the hippocampus", EXP BRAIN R, 141(3), 2001, pp. 304-311

Abstract

Recent studies have questioned the importance of the entorhinal cortex (ERC) for normal hippocampal function. For example, fibre-sparing ERC lesions have been found to have no effect on spatial learning in the watermaze. There is also doubt as to the importance of the ERC for contextual fear conditioning, with previous studies having yielded conflicting results. In an attempt to resolve this issue, the present study compared aspiration and cytotoxic ERC lesioned rats, along with fimbria-fornix (FFX) lesioned animals and sham operated controls, on an unsignalled contextual fear conditioning paradigm. The results of the present study show that whereas lesions of the FFX disrupted contextual freezing, neither aspiration nor cytotoxic ERC lesions had any effect on this behaviour. Aspiration ERC lesioned rats, however, like FFX lesioned animals, did display hyperactivity prior to the delivery of footshock. These results suggest that whereas projections between the hippocampus and subcortical structures are important for normal levels of contextual freezing, projections from the entorhinal cortex are not essential.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:02:45