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Titolo:
The role of the entorhinal cortex in two forms of spatial learning and memory
Autore:
Bannerman, DM; Yee, BK; Lemaire, M; Wilbrecht, L; Jarrard, L; Iversen, SD; Rawlins, JNP; Good, MA;
Indirizzi:
Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England Univ Oxford Oxford England OX1 3UD Expt Psychol, Oxford OX1 3UD, England Univ Hong Kong, Fac Med, Dept Anat, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Porsolt & Partners Pharmacol, F-92100 Boulogne, France Porsolt & Partners Pharmacol Boulogne France F-92100 00 Boulogne, France Rockefeller Univ, Lab Anim Behav, New York, NY 10021 USA Rockefeller UnivNew York NY USA 10021 Anim Behav, New York, NY 10021 USA Washington & Lee Univ, Dept Psychol, Lexington, VA 24450 USA Washington & Lee Univ Lexington VA USA 24450 hol, Lexington, VA 24450 USA Univ Wales Coll Cardiff, Sch Psychol, Cardiff CF10 3YG, S Glam, Wales UnivWales Coll Cardiff Cardiff S Glam Wales CF10 3YG 3YG, S Glam, Wales
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 3, volume: 141, anno: 2001,
pagine: 281 - 303
SICI:
0014-4819(200112)141:3<281:TROTEC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SULFIDE SILVER METHOD; MORRIS WATER MAZE; MEDIAL SEPTAL-LESIONS; PERIRHINAL CORTEX; HIPPOCAMPAL-FORMATION; WORKING-MEMORY; DENTATE GYRUS; LATENT INHIBITION; FASCIA DENTATA; ADULT-RATS;
Keywords:
entorhinal cortex; hippocampus; fimbria fornix; spatial learning; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Bannerman, DM Univ Oxford, Dept Expt Psychol, S Parks Rd, Oxford OX1 3UD, England Univ Oxford S Parks Rd Oxford England OX1 3UD 3UD, England
Citazione:
D.M. Bannerman et al., "The role of the entorhinal cortex in two forms of spatial learning and memory", EXP BRAIN R, 141(3), 2001, pp. 281-303

Abstract

It is generally acknowledged that the rodent hippocampus plays an important role in spatial learning and memory. The importance of the entorhinal cortex (ERC), an area that is closely interconnected anatomically with the hippocampus, in these forms of learning is less clear cut. Recent studies using selective, fibre-sparing cytotoxic lesions have generated conflicting results, with some studies showing that spatial learning can proceed normally without the ERC, suggesting that this area is not required for normal hippocampal function. The present study compared cytotoxic and aspiration ERC lesions with both fimbria fornix (FFX) lesions and sham-operated controls on two spatial learning tasks which have repeatedly been shown to depend on the hippocampus. Both groups of ERC lesions were impaired during nonmatching-to-place testing (rewarded alternation) on the elevated T-maze. However, neither of these lesions subsequently had any effect on the acquisition of a standard spatial reference memory task in the water maze. FFX lesions produced a robust and reliable impairment on both of these tasks. A second experiment confirmed that cytotoxic ERC lesions spared water maze learning but disrupted rewarded alternation on the T-maze, when the order of behavioural testing was reversed. These results confirm previous reports that ERC-lesioned animals are capable of spatial navigation in the water maze, suggestingthat the ERC is not a prerequisite for normal hippocampal function in thistask. The present demonstration that ERC lesions disrupt non-matching-to-place performance may, however, be consistent with the possibility that ERC lesions affect attentional mechanisms, for example, by increasing the sensitivity to recent reward history.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:07:53