Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of antagonism of NMDA receptors on transient lower esophageal sphincter relaxations in the dog
Autore:
Lehmann, A; Branden, L;
Indirizzi:
AstraZeneca R&D Molndal, Gastrointestinal Biol, Integrat Pharmacol, S-43183 Molndal, Sweden AstraZeneca R&D Molndal Molndal Sweden S-43183 , S-43183 Molndal, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 431, anno: 2001,
pagine: 253 - 258
SICI:
0014-2999(20011116)431:2<253:EOAONR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; GASTROESOPHAGEAL REFLUX; GASTRIC DISTENSION; TRANSMISSION; MECHANISM; RAT;
Keywords:
vagus; glutamate; dorsal vagal complex; motility; gastro-esophageal reflux;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Lehmann, A AstraZeneca R&D Molndal, Gastrointestinal Biol, Integrat Pharmacol, S-43183 Molndal, Sweden AstraZeneca R&D Molndal Molndal Sweden S-43183 olndal, Sweden
Citazione:
A. Lehmann e L. Branden, "Effects of antagonism of NMDA receptors on transient lower esophageal sphincter relaxations in the dog", EUR J PHARM, 431(2), 2001, pp. 253-258

Abstract

Transient lower esophageal sphincter relaxation is the major cause of gastroesophageal reflux. Mechanisms underlying transient lower esophageal sphincter relaxation are poorly understood although gastric mechanosensitive vagal afferent pathways play a central role. Glutamate is a key transmitter ofvagal afferents acting partly on NMDA receptors. The aim of this work was to study the effects on transient lower esophageal sphincter relaxation in awake dogs (n = 5) of the competitive NMDA receptor antagonist cis-4-phosphono-methyl-2-piperidine carboxylic acid (CGS 19755; 0.3 and 3 mg/kg i.v., the high dose was given at two separate occasions to each dog). Transient lower esophageal sphincter relaxations were evoked by intragastric infusion of a liquid meal followed by air insufflation and were scored during a 45-min period. Neither dose produced. any significant effect on the group average number of transient lower esophageal sphincter relaxations. Synchronous contractions of the esophagus were commonly seen during transient lower esophageal sphincter relaxation and CGS 19755 at both doses greatly reduced their occurrence. The findings indicate that NMDA receptor antagonism selectively inhibits the esophageal component of transient lower esophageal sphincter relaxation although the rate of transient lower esophageal sphincter relaxations is not consistently affected. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:49:44