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Titolo:
Influence of neurosteroids on the development of rapid tolerance to ethanol in mice
Autore:
Barbosa, ADE; Morato, GS;
Indirizzi:
Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Farmacol, BR-88015420 Florianopolis, SC, Brazil Univ Fed Santa Catarina Florianopolis SC Brazil BR-88015420 BC SC, Brazil
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 431, anno: 2001,
pagine: 179 - 188
SICI:
0014-2999(20011116)431:2<179:IONOTD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GABA-A RECEPTOR; D-ASPARTATE RECEPTOR; PREGNENOLONE SULFATE; NEUROACTIVE STEROIDS; DEHYDROEPIANDROSTERONE SULFATE; HIPPOCAMPAL-NEURONS; NMDA ANTAGONIST; POTENTIATION; MECHANISMS; MODULATORS;
Keywords:
tolerance; ethanol; pregnenolone sulfate; dehydroepiandrosterone sulfate; (+)-MK-801; muscimol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Morato, GS Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Farmacol, Rua Ferreira Lima 82, BR-88015420 Florianopolis, SC, Brazil Univ Fed Santa Catarina Rua Ferreira Lima 82 Florianopolis SC Brazil BR-88015420 BC
Citazione:
A.D.E. Barbosa e G.S. Morato, "Influence of neurosteroids on the development of rapid tolerance to ethanol in mice", EUR J PHARM, 431(2), 2001, pp. 179-188

Abstract

Our recent study demonstrated that neurosteroids might either facilitate or block chronic tolerance to the incoordinating effects of ethanol. The present study investigated the effects of neurosteroids on the development of rapid tolerance to ethanol-induced motor impairment using the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine [(+)-MK-801] or the gamma -aminobutyric acid (GABA) type A (GABA(A)) receptor agonist muscimol. Male Swiss mice were pretreated with pregnenolone sulfate (0.03 to 0.15 mg/kg) or dehydroepiandrosterone sulfate (0.05 to 0.20 mg/kg) before administration of ethanol (1.9 or 2.25 g/kg) and tested with the rota-rod apparatus. Twenty-four hours later, all animals were re-tested with the rota-rod after receiving the same dose of ethanol. Pretreatment with pregnenolone sulfate or with dehydroepiandrosterone sulfate significantly facilitated the acquisitionof tolerance. However, the administration of (+)-MK-801 reversed the stimulatory action of pregnenolone sulfate but did not affect the actions of dehydroepiandrosterone sulfate on ethanol tolerance. Pretreatment with pregnenolone sulfate or dehydroepiandrosterone sulfate prevented the inhibitory action of muscimol on tolerance development. Taken together, our results suggest that neurosteroids may stimulate the development of rapid tolerance to ethanol and that GABA(A) and NMDA receptor systems may be involved in theseactions. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:51:49