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Titolo:
Effects of ketamine on different types of anxiety/fear and related memory in rats with lesions of the median raphe nucleus
Autore:
Babar, E; Ozgunen, T; Melik, E; Polat, S; Akman, H;
Indirizzi:
Cukurova Univ, Fac Med, Dept Physiol, Div Neurophysiol, TR-01330 Adana, Turkey Cukurova Univ Adana Turkey TR-01330 Neurophysiol, TR-01330 Adana, Turkey Cukurova Univ, Fac Med, Dept Histol, Div Neurophysiol, TR-01330 Adana, Turkey Cukurova Univ Adana Turkey TR-01330 Neurophysiol, TR-01330 Adana, Turkey Cukurova Univ, Fac Med, Dept Anaesthesiol, Div Neurophysiol, TR-01330 Adana, Turkey Cukurova Univ Adana Turkey TR-01330 Neurophysiol, TR-01330 Adana, Turkey
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 431, anno: 2001,
pagine: 315 - 320
SICI:
0014-2999(20011123)431:3<315:EOKODT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONCOMPETITIVE NMDA ANTAGONIST; PREFRONTAL CORTEX; BRAIN-REGIONS; DORSAL; MICE; SEROTONIN; AMYGDALA; SHOCK; 5-HT; PHENCYCLIDINE;
Keywords:
ketamine; median raphe nucleus; 5-HT (5-hydroxytryptamine, serotonin); anxiety; fear; memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Babar, E Cukurova Univ, Fac Med, Dept Physiol, Div Neurophysiol, TR-01330 Adana, Turkey Cukurova Univ Adana Turkey TR-01330 iol, TR-01330 Adana, Turkey
Citazione:
E. Babar et al., "Effects of ketamine on different types of anxiety/fear and related memory in rats with lesions of the median raphe nucleus", EUR J PHARM, 431(3), 2001, pp. 315-320

Abstract

The aim of the present study was to determine the involvement of the median raphe serotonergic system in the effects of ketamine on anxiety behaviours, and related memory. The effects of ketamine pretreatment (3 and 10 mg/kg, i.p.) on three types of fear-motivated behaviours, unconditioned one-way escape, conditioned avoidance and freezing were tested. Experiments were performed with the inhibitory avoidance apparatus in rats with ibotenic acid lesions of the median raphe nucleus. It was found that 10 mg/kg ketamine had an anxiogenic-like effect on one-way escape type of fear and anxiolytic-like effect on conditioned freezing-related fear; these effects were unaffected by median raphe lesions, Both ketamine doses impaired freezing-related fear memory. Ketamine (10 mg/kg) also produced an anxiolytic-like effect onavoidance type of fear and impaired avoidance memory. The median raphe lesions attenuated the anxiolytic action of the drug on the avoidance type of fear and prevented ketamine-induced avoidance memory impairment. These results suggest that the anxiolytic-like effect of ketamine on avoidance-type fear is mediated through the median raphe serotonergic system. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 09:32:10