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Titolo:
Evaluation of nonglucose carbohydrates in parenteral nutrition for diabetic patients
Autore:
Valero, MA; Leon-Sanz, M; Escobar, I; Gomis, P; de la Camara, A; Moreno, JM;
Indirizzi:
Hosp Doce Octubre, Serv Pharm, Madrid, Spain Hosp Doce Octubre Madrid Spain Doce Octubre, Serv Pharm, Madrid, Spain
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 12, volume: 55, anno: 2001,
pagine: 1111 - 1116
SICI:
0954-3007(200112)55:12<1111:EONCIP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCEROL; XYLITOL; COMPLICATIONS; MANAGEMENT; METABOLISM; FRUCTOSE; GLUCOSE;
Keywords:
parenteral nutrition; diabetes mellitus; glucose; fructose; xylitol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Gomis, P Hosp 12 Octubre, Serv Pharm, Carretera Andalucia,Km 5-4, E-28041 Madrid, Spain Hosp 12 Octubre Carretera Andalucia,Km 5-4 Madrid Spain E-28041
Citazione:
M.A. Valero et al., "Evaluation of nonglucose carbohydrates in parenteral nutrition for diabetic patients", EUR J CL N, 55(12), 2001, pp. 1111-1116

Abstract

Objective: There is little information on the advantages of nonglucose carbohydrates in total parenteral nutrition (TPN) for diabetic patients. The aim of this study is to evaluate glycemic control and insulin requirements in diabetic patients who received TPN with different sources of carbohydrates, and to determine whether insulin requirements are different when septic and non-septic diabetic patients are studied. Materials and Methods: One-hundred and thirty-eight patients were randomlydivided into two groups receiving either glucose (G), n = 71, or glucose-fructose-xylitol 2:1:1 (GFX), n = 67. There were no differences between the demographic or anthropometric characteristics of the groups, nor between the patients with diabetes mellitus type I and type 2, nor the initial TPN composition. Acceptable glycemic control was considered when glycemia reached< 200 mg/dl. Results: Glycemic control was attained in 79.7% of patients (74.6 vs 85.1%in the same period of treatment. At the end of treatment, insulin requirements were not different (45 +/- 19 vs 45 +/- 26 UI/day) in both groups, while similar amounts of carbohydrates (191 +/- 36 vs 187 +/- 45 g/day) were infused. The ratio insulin/body weight and insulin/carbohydrates were equal in both groups. In the GFX group nonseptic and septic patients needed less and more insulin, respectively, than their counterparts in the G group. No major adverse events related to carbohydrate infusions were observed. Conclusions: Either G or GFX could be used in TPN for diabetic patients, providing glycemic control in most cases with similar insulin requirements. GFX mixtures were slightly more beneficial to attain glycemic control in nonseptic patients, but septic diabetic patients had higher insulin needs in this group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 05:27:26