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Titolo:
Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery
Autore:
Alexiou, D; Karayiannakis, AJ; Syrigos, KN; Zbar, A; Kremmyda, A; Bramis, I; Tsigris, C;
Indirizzi:
Democritus Univ Thrace, Sch Med, Dept Surg 2, Alexandroupolis 68100, Greece Democritus Univ Thrace Alexandroupolis Greece 68100 upolis 68100, Greece Univ Athens, Sch Med, Dept Surg 1, GR-11527 Athens, Greece Univ Athens Athens Greece GR-11527 Dept Surg 1, GR-11527 Athens, Greece Univ Athens, Sch Med, Dept Med 3, GR-11527 Athens, Greece Univ Athens Athens Greece GR-11527 , Dept Med 3, GR-11527 Athens, Greece Kaplan Med Ctr, Dept Surg, IL-76100 Rehovot, Israel Kaplan Med Ctr Rehovot Israel IL-76100 pt Surg, IL-76100 Rehovot, Israel
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 18, volume: 37, anno: 2001,
pagine: 2392 - 2397
SICI:
0959-8049(200112)37:18<2392:SLOEIA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; SOLUBLE E-SELECTIN; ENDOTHELIAL-CELLS; COLON-CARCINOMA; EXPRESSION; CYTOTOXICITY; DISTINCT; BINDING; ANTIGEN; ELAM-1;
Keywords:
cell adhesion molecule; E-selectin; ICAM-1; VCAM-1; surgery; prognosis; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Karayiannakis, AJ Democritus Univ Thrace, Sch Med, Dept Surg 2, Alexandroupolis 68100, Greece Democritus Univ Thrace Alexandroupolis Greece 68100 ce
Citazione:
D. Alexiou et al., "Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery", EUR J CANC, 37(18), 2001, pp. 2392-2397

Abstract

The serum concentrations oft he cell adhesion molecules E-select in, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1(VCAM-1) were investigated in 63 patients with colorectal cancer and in 51controls by an enzyme-linked immunosorbent assay (ELISA). Their relationship to clinicopathological variables and patient survival and changes in their levels after surgery were examined. Colorectal cancer patients showed significantly higher serum levels of E-selectin, ICAM-1 and VCAM-1 compared with healthy controls. There was a significant association between. the serum levels of these molecules, disease stage and the presence of both lymph node and distant metastases. Both ICAM-1 and VCAM-1 levels correlated with serum E-selectin and carcinoembryonic antigen (CEA) levels. Serum levels of all three molecules decreased significantly after radical resection of the tumour. Elevated pre-operative E-selectin. ICAM-1 and VCAM-1 levels were significant prognostic factors, although not independent of stage. for patient survival. These findings suggest that serum concentrations of E-selectin,ICAM-1 and VCAM-1 may reflect tumour progression and metastasis. Since these markers are linked to CEA levels, it is uncertain whether their measurement will prove cost-effective in colorectal cancer management. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:47:13