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Titolo:
Locally advanced primary breast cancer: medium-term results of a randomised trial of multimodal therapy versus initial hormone therapy
Autore:
Tan, SM; Cheung, KL; Willsher, PC; Blamey, RW; Chan, SY; Robertson, JFR;
Indirizzi:
City Hosp Nottingham, Dept Surg, Nottingham, England City Hosp NottinghamNottingham England Dept Surg, Nottingham, England City Hosp Nottingham, Dept Clin Oncol, Nottingham, England City Hosp Nottingham Nottingham England Clin Oncol, Nottingham, England
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 18, volume: 37, anno: 2001,
pagine: 2331 - 2338
SICI:
0959-8049(200112)37:18<2331:LAPBCM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANAGEMENT;
Keywords:
locally advanced primary breast cancer; multimodal therapy; hormone therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Robertson, JFR City Hosp Nottingham, Dept Surg, Nottingham, England City Hosp Nottingham Nottingham England tingham, England
Citazione:
S.M. Tan et al., "Locally advanced primary breast cancer: medium-term results of a randomised trial of multimodal therapy versus initial hormone therapy", EUR J CANC, 37(18), 2001, pp. 2331-2338

Abstract

We report the medium-term (median follow-up = 52 months) results of a prospective randomised trial of multimodal therapy (neoadjuvant chemotherapy, Patey mastectomy, postoperative radiotherapy and adjuvant hormone therapy) (n = 56) versus initial hormone therapy (n = 52) for locally advanced primary breast cancer. Compared with multimodal therapy, initial hormone therapy was associated with reduced number of therapies for disease control (mean =3.6 versus 4.9) and mastectomy rate (31%). Multimodal therapy conferred better initial locoregional control and a longer disease-free interval. Nevertheless, there was no statistically significant differences in the rates ofsurvival, metastasis and uncontrolled locoregional disease, as well as in the time to metastasis between the two therapy groups. Regardless of the therapy groups, oestrogen receptor positivity conferred a lower metastasis rate, better survival and locoregional control. Thus, initial hormone therapymay be a reasonable option for managing locally advanced primary breast cancer, especially for oestrogen receptor-positive tumours. (C) 2001 Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:32:51