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Titolo:
CBP/p300 and muscle differentiation: no HAT, no muscle
Autore:
Polesskaya, A; Naguibneva, I; Fritsch, L; Duquet, A; Ait-Si-Ali, S; Robin, R; Vervisch, A; Pritchard, LL; Cole, P; Harel-Bellan, A;
Indirizzi:
CNRS, UPR 9079, F-94800 Villejuif, France CNRS Villejuif France F-94800CNRS, UPR 9079, F-94800 Villejuif, France Inst Andre Lwoff, Serv Cytofluorometrie, F-94800 Villejuif, France Inst Andre Lwoff Villejuif France F-94800 rie, F-94800 Villejuif, France Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205USA Johns Hopkins Univ Baltimore MD USA 21205 Mol Sci, Baltimore, MD 21205USA
Titolo Testata:
EMBO JOURNAL
fascicolo: 23, volume: 20, anno: 2001,
pagine: 6816 - 6825
SICI:
0261-4189(200112)20:23<6816:CAMDNH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKING HISTONE ACETYLATION; CELL-CYCLE ARREST; SKELETAL-MUSCLE; RETINOBLASTOMA PROTEIN; COACTIVATORS P300; TRANSFERASE ACTIVITY; TRANSCRIPTION FACTOR; E1A-ASSOCIATED P300; MOUSE DEVELOPMENT; GENE-EXPRESSION;
Keywords:
CREB-binding protein (CBP); histone acetyltransferase; MyoD; myogenesis; p300;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Harel-Bellan, A CNRS, UPR 9079, 7 Rue Guy Moquet, F-94800 Villejuif, France CNRS 7 Rue Guy Moquet Villejuif France F-94800 if, France
Citazione:
A. Polesskaya et al., "CBP/p300 and muscle differentiation: no HAT, no muscle", EMBO J, 20(23), 2001, pp. 6816-6825

Abstract

Terminal differentiation of muscle cells follows a precisely orchestrated program of transcriptional regulatory events at the promoters of both muscle-specific and ubiquitous genes. Two distinct families of transcriptional co-activators, GCN5/PCAF and CREB-binding protein (CBP)/p300, are crucial tothis process. While both possess histone acetyl-transferase (HAT) activity, previous studies have failed to identify a requirement for CBP/p300 HAT function in myogenic differentiation. We have addressed this issue directly using a chemical inhibitor of CBP/p300 in addition to a negative transdominant mutant. Our results clearly demonstrate that CBP/p300 HAT activity is critical for myogenic terminal differentiation. Furthermore, this requirement is restricted to a subset of events in the differentiation program: cell fusion and specific gene expression. These data help to define the requirements for enzymatic function of distinct coactivators at different stages ofthe muscle cell differentiation program.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 21:05:41